1: thiophene-2-carboxylic acid With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 2 h; Cooling with isopropanol-dry ice; 2: carbon dioxide in tetrahydrofuran; hexanes T=-78°C; 1 h; 3: With hydrogenchloride in tetrahydrofuran; hexanes; water T=-10 - 20°C;
1: thiophene-2-carboxylic acid in tetrahydrofuran T=-78°C; 0.5 h; Cooling with isopropanol - dry ice; 2: With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 1.5 h; Cooling with isopropanol - dry ice; 3: carbon dioxide With hydrogenchloride Product distribution / selectivity; more than 3 stages;
参考文献
BAYER HEALTHCARE AG
Patent: WO2007/118602 A1, 2007 ;
Location in patent: Page/Page column 55; 56 ;
Carpenter, Andrew J.; Chadwick, Derek J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 173 - 182
