2'-羟基-5'-硝基苯乙酮合成路线 （共 49 条）
参考文献
Tetrahedron Letters, , vol. NO. 16, p. 1393 - 1396
反应条件
piperidine 0.166667 h; Neat (no solvent)Microwave irradiation;
参考文献
Tripathi; Koul; Taneja
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 2 p. 301 - 304
反应条件
1: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 10 h / 75 °C 2: water / 12 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / methanol / 20 °C / 1034.32 Torr 4: triethylamine / tetrahydrofuran / 48 h / 40 °C 5: hydrogenchloride / acetone / 1.5 h / 20 °C / pH 5.5 - 6 View Scheme
参考文献
Joshi, Ramesh A.; Gurjar, Mukund K.; Tripathy, Narendra K.; Chorghade, Mukund S.
Organic Process Research and Development, 2001 , vol. 5, # 2 p. 176 - 178
反应条件
potassium carbonate in acetone T=60°C; 12 h;
参考文献
Dey, Sangeeta; Powell, Douglas R.; Hu, Chunhua; Berkowitz, David B.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 37 p. 7010 - 7014
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate T=75°C; 10 h;
参考文献
Joshi, Ramesh A.; Gurjar, Mukund K.; Tripathy, Narendra K.; Chorghade, Mukund S.
Organic Process Research and Development, 2001 , vol. 5, # 2 p. 176 - 178
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran P=2068.6 Torr; 2 h;
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
反应条件
1: N,N-dimethyl-formamide With bis(trichloromethyl) carbonate in 1,2-dichloro-ethane T=0 - 20°C; 2: 2-hydroxy-5-nitro-acetophenone in 1,2-dichloro-ethane T=0 - 20°C; 6.5 h; Further stages.;
参考文献
Organic Preparations and Procedures International, , vol. 39, # 5 p. 495 - 502
反应条件
1: N,N-dimethyl-formamide With bis(trichloromethyl) carbonate in 1,2-dichloro-ethane T=0 - 20°C; 2: 2-hydroxy-5-nitro-acetophenone in 1,2-dichloro-ethane T=0 - 20°C; 6.5 h; Further stages.;
参考文献
Organic Preparations and Procedures International, , vol. 39, # 5 p. 495 - 502
反应条件
hydrazine T=150°C; 0.0833333 h; Microwave irradiation;
参考文献
DAEWOONG PHARMACEUTICAL CO., LTD.
Patent: WO2006/109933 A1, 2006 ;
Location in patent: Page/Page column 48-49 ;
反应条件
sodium ethanolate in ethanol; hexane; water; toluene
参考文献
Kanter, James; Mullins, John J.G.; Pandey, Anjali; Scarborough, Robert
Patent: US2003/233002 A1, 2003 ;
Location in patent: Page 15 ;
