1-甲基-2-(甲硫基)咪唑合成路线 （共 12 条）
反应条件
1: 1-methyl-1H-imidazole With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 2: With sulfur in tetrahydrofuran; hexane 12 h; Heating; 3: methyl iodide in tetrahydrofuran; hexane T=20°C; 4 h;
参考文献
Roy, Gouriprasanna; Mugesh
Journal of the American Chemical Society, 2005 , vol. 127, # 43 p. 15207 - 15217
反应条件
n-butyllithium 1) hexane, THF, -78 deg C; 2) hexane, THF, room temperature, overnight; Yield given. Multistep reaction;
参考文献
Chauviere, Gerard; Bouteille, Bernard; Enanga, Bertin; De Albuquerque, Cristina; Croft, Simon L.; Dumas, Michel; Perie, Jacques
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 427 - 440
参考文献
Roussel Uclaf
Patent: US5663164 A1, 1997 ;
反应条件
sodium methylate in methanol 1 h; Heating;
参考文献
Bojarska-Olejnik, E.; Stefaniak, L.; Witanowski, M.; Hamdi, B. T.; Webb, G. A.
Magnetic Resonance in Chemistry, 1985 , vol. 23, # 3 p. 166 - 169
反应条件
in acetic acid 11 h; Heating;
参考文献
Pooranchand, Dinah; Ila, Hiriyakkanavar; Junjappa, Hiriyakkanavar
Synthesis, 1987 , # 12 p. 1136 - 1138
反应条件
sulfuric acid 8 h; Reflux;
参考文献
Shimizu, Masao; Shimazaki, Teruaki; Kon, Yoshihiro; Konakahara, Takeo
Heterocycles, 2010 , vol. 81, # 2 p. 413 - 420
反应条件
sodium carbonate 1 h; Ambient temperature;
参考文献
Vampa; Benvenuti; Severi; Malmusi; Antolini
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 227 - 234
反应条件
n-butyllithium 1.) Et2O, reflux, 6 h, 2.) -78 deg C, 5 min; room temperature, 17 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Carpenter, Andrew J.; Chadwick, Derek J.; Ngochindo Raphael I.
Journal of Chemical Research, Miniprint, 1983 , # 8 p. 1913 - 1941
反应条件
1: 45 percent / aq. HNO3 / 1 h 2: 90 percent / TFA; H2O2 / 1 h / 40 °C View Scheme
参考文献
Chauviere, Gerard; Bouteille, Bernard; Enanga, Bertin; De Albuquerque, Cristina; Croft, Simon L.; Dumas, Michel; Perie, Jacques
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 427 - 440
参考文献
Chauviere, Gerard; Bouteille, Bernard; Enanga, Bertin; De Albuquerque, Cristina; Croft, Simon L.; Dumas, Michel; Perie, Jacques
Journal of Medicinal Chemistry, 2003 , vol. 46, # 3 p. 427 - 440
