N-甲氧基-2-(3-甲氧基苯基)-n-甲基乙酰胺合成路线 （共 5 条）
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C;
参考文献
MERCK SHARP and DOHME CORP.; DWYER, Michael P; KEERTIKAR, Kartik M; COBURN, Craig A; WU, Hao; HU, Bin; ZHONG, Bin; ZHANG, Chengren; DAN, Zhigang; TONG, Ling; YU, Wensheng
Patent: WO2012/41227 A1, 2012 ;
Location in patent: Page/Page column 116 ;
WO 2012/041227 A1
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane T=0°C; 12 h; Inert atmosphere;
参考文献
Duong, Hung A.; Gilligan, Ruth E.; Cooke, Michael L.; Phipps, Robert J.; Gaunt, Matthew J.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 2 p. 463 - 466
反应条件
1: (3-methoxy-phenyl)-acetic acid With 1,1'-carbonyldiimidazole in dichloromethane T=20°C; 2: O,N-dimethyl-hydroxylamine hydrochloride in dichloromethane T=20°C;
参考文献
Ghosh, Arun K.; Martyr, Cuthbert D.; Xu, Chun-Xiao
Organic Letters, 2012 , vol. 14, # 8 p. 2002 - 2005
反应条件
1: thionyl chloride; N,N-dimethyl-formamide / toluene / 3 h / 70 °C / Inert atmosphere 2: potassium carbonate / water; toluene / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Wang, Hengbin; Denton, Justin R.; Davies, Huw M. L.
Organic Letters, 2011 , vol. 13, # 16 p. 4316 - 4319
反应条件
in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
MERCK SHARP and DOHME CORP.; DWYER, Michael P; KEERTIKAR, Kartik M; COBURN, Craig A; WU, Hao; HU, Bin; ZHONG, Bin; ZHANG, Chengren; DAN, Zhigang; TONG, Ling; YU, Wensheng
Patent: WO2012/41227 A1, 2012 ;
Location in patent: Page/Page column 117 ;
WO 2012/041227 A1
