5-乙基-2-吡啶乙醇对甲苯磺酸盐合成路线 （共 7 条）
反应条件
1: 2-(5-ethyl-pyridin-2-yl)ethanol With sodium hydroxide in dichloromethane; water 2 h; 2: p-toluenesulfonyl chloride in dichloromethane; water T=20°C;
参考文献
WO2009/148195 A1, ;
Page/Page column 4-5; 21 ;
反应条件
in dimethyl sulfoxide T=25 - 40°C; 7 h;
参考文献
WO2004/108721 A1, ;
Page 8-9 ;
反应条件
potassium hydroxide in N,N-dimethyl-formamide T=45°C; 2 h;
参考文献
Richter, Jindrich; Jirman; Havlicek; Hrdina
Pharmazie, 2007 , vol. 62, # 8 p. 580 - 584
反应条件
sodium hydroxide in dichloromethane
参考文献
Mohanty, Sandeep; Reddy. G, Sandeep; Karmakar, Arun Chandra
Letters in Organic Chemistry, 2014 , vol. 11, # 3 p. 197 - 202
反应条件
1: 2,4-dioxo-5-[(p-hydroxyphenyl)-methyl]thiazolidine With potassium hydroxide in ethanol T=20°C; 1 h; 2: toluene-4-sulfonic acid-2-(5-ethylpyridin-2-yl)-ethyl ester in ethanol Reflux; Product distribution / selectivity;
参考文献
DAEBONG LS, LTD.
Patent: WO2009/148195 A1, 2009 ;
Location in patent: Page/Page column 9; 15; 21-22; 27 ;
反应条件
1: potassium carbonate / toluene / |Reflux 2: sodium hydrogensulfite / water; hexane 3: trichlorophosphate / toluene / 8 h / |Reflux View Scheme
参考文献
Mohanty, Sandeep; Reddy. G, Sandeep; Karmakar, Arun Chandra
Letters in Organic Chemistry, 2014 , vol. 11, # 3 p. 197 - 202
反应条件
potassium hydroxide in N,N-dimethyl-formamide
T=45°C; 2 h;
参考文献
Richter, Jindrich; Jirman; Havlicek; Hrdina
Pharmazie, 2007 , vol. 62, # 8 p. 580 - 584
