2-氧代吡咯烷-1-羧酸苄酯合成路线 （共 14 条）
反应条件
1.1: 88 percent / DIBAL-H / tetrahydrofuran; hexane / 1 h / -78 °C
2.1: (CF3CO)2O / toluene / 7 h / -78 °C
2.2: 70 percent / 2,6-lutidine / 0.33 h / Heating
View Scheme
参考文献
Marais, Wilhelmina; Holzapfel, Cedric W.
Synthetic Communications, 1998 , vol. 28, # 19 p. 3681 - 3691
反应条件
lithium triethylborohydride in tetrahydrofuran
T=-78°C; 1 h;
参考文献
Piperno, Anna; Carnovale, Caterina; Giofr, Salvatore V.; Iannazzo, Daniela
Tetrahedron Letters, 2011 , vol. 52, # 51 p. 6880 - 6882
反应条件
1: furan With n-butyllithium in tetrahydrofuran
T=0 - 20°C; 0.25 h; Inert atmosphere;
2: N-Cbz-2-pyrrolidinone in tetrahydrofuran
T=-78°C; 0.25 h;
参考文献
Coral, Jason A.; Guo, Haibing; Shan, Mingde; O'Doherty, George A.
Heterocycles, 2009 , vol. 79, # C p. 521 - 529
反应条件
magnesium
1.) THF, 2.) -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille
Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234
