1-Boc-3-[(二甲氨基)甲基]-7-氮杂吲哚合成路线 （共 5 条）
反应条件
1: 3-(N,N-dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine With sodium hydride in tetrahydrofuran 0.166667 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C;
参考文献
PLEXXIKON, INC.
Patent: WO2008/63888 A2, 2008 ;
Location in patent: Page/Page column 60 ;
反应条件
1: 80 percent / glacial acetic acid / H2O / 16 h / 60 °C 2: 1.) NaH / 1.) HMPA, 0.5 h, 2.) HMPA, 21 deg C, 2 h View Scheme
参考文献
ASCEPION PHARMACEUTICALS, INC.; JIANG, Shan; XING, Xinglong; WANG, Qishan; KONG, Ren
Patent: WO2011/23081 A1, 2011 ;
WO 2011/023081 A1
反应条件
in toluene T=20°C; 3 h;
参考文献
PLEXXIKON, INC.
Patent: WO2008/63888 A2, 2008 ;
Location in patent: Page/Page column 60 ;
反应条件
isobutyl chloroformate in toluene Inert atmosphere;
参考文献
ASCEPION PHARMACEUTICALS, INC.; JIANG, Shan; XING, Xinglong; WANG, Qishan; KONG, Ren
Patent: WO2011/23081 A1, 2011 ;
Location in patent: Page/Page column 54 ;
WO 2011/023081 A1
反应条件
in ethanol 1.) 0 deg C, 1h, 2.) 5 deg C, 4 d;
参考文献
Sanchez-Obregon, Ruben; Fallis, Alex G.; Szabo, Arthur G.
Canadian Journal of Chemistry, 1992 , vol. 70, # 5 p. 1531 - 1536
