(1S)-1-(3-吡啶基)-3-丁烯-1-醇合成路线 （共 9 条）
反应条件
tin; (S)-1-acetyl-N-tosylpyrrolidine-2-carboxamide in water; N,N-dimethyl-formamide T=20°C; 24 h; Overall yield = 83 percent; enantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 24, # 20 p. 1324 - 1330
反应条件
in diethyl ether T=-100°C; Addition; 1 h; Title compound not separated from byproducts;
参考文献
Synlett, , # 11 p. 1646 - 1648
反应条件
Pseudomonas cepacia lipase immobilized on modified ceramic in tetrahydrofuran T=24°C; 30 h;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 24 p. 2679 - 2687
反应条件
1: 72 percent / indium / tetrahydrofuran; H2O / 12 h / 30 °C 2: 50 percent / Pseudomonas cepacia lipase immobilized on modified ceramic / tetrahydrofuran / 30 h / 24 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 24 p. 2679 - 2687
反应条件
in tetrahydrofuran T=-100°C; 1 h; Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 66, # 19 p. 6305 - 6312
反应条件
1: 60 percent / DMP / CH2Cl2 / 0.5 h / 20 °C 2: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 37 p. 7381 - 7389
反应条件
in diethyl ether T=-100°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 41, # 48 p. 9245 - 9249
反应条件
8-hydroxy-quinoline 1) anh. ether, -100 deg C, 1 h, 2) methanol, 25 deg C, 12 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 57, # 24 p. 6614 - 6617
反应条件
1: Et3N / CH2Cl2 / 0 °C 2: NaN3 / dimethylformamide / 60 °C 3: 85 percent / dicyclohexylborane / tetrahydrofuran / 12 h / 0 - 20 °C 4: Et3N / diethyl ether / 20 °C 5: LiAlH4 / tetrahydrofuran / 0 °C View Scheme
参考文献
Girard; Robins; Villieras; Lebreton
Tetrahedron Letters, 2000 , vol. 41, # 48 p. 9245 - 9249
