(S)-(-)-1-苯基乙醇合成路线 （共 393 条）
反应条件
Candida antarctica lipase B; (η5-C5Ph5)Ru(CO)2Cl; potassium tert-butylate; sodium carbonate in tetrahydrofuran; toluene T=20°C; 3 h;
参考文献
Martin-Matute, Belen; Edin, Michaela; Bogar, Krisztian; Kaynak, F. Betuel; Baeckvall, Jan-E.
Journal of the American Chemical Society, 2005 , vol. 127, # 24 p. 8817 - 8825
反应条件
1: With bis(η3-allyl-μ-chloropalladium(II)); C33H31OP; trichlorosilane T=20°C; 18 h; 2: With potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate in tetrahydrofuran; methanol T=20°C; 16 h;
参考文献
Duclos, Marie-Christine; Singjunla, Yuttapong; Petit, Christelle; Favre-Reguillon, Alain; Popowycz, Florence; Metay, Estelle; Lemaire, Marc; Jeanneau, Erwann
Tetrahedron Letters, 2012 , vol. 53, # 45 p. 5984 - 5986,3
反应条件
immobilized Candida antarctica Lipase B; potassium carbonate; chiral ruthenium-based in toluene T=70°C; P=150.012 Torr; 24 h;
参考文献
van Nispen, Sjoerd F.G.M.; van Buijtenen, Jeroen; Vekemans, Jef A.J.M.; Meuldijk, Jan; Hulshof, Lumbertus A.
Tetrahedron Asymmetry, 2006 , vol. 17, # 15 p. 2299 - 2305
反应条件
bis(acetylacetonate)nickel(II); C64H93NO8P2 in tetrahydrofuran T=5°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Letters, , vol. 50, # 31 p. 4495 - 4497
反应条件
sodium hydroxide; dihydrogen peroxide in diethyl ether T=0 - 20°C; Oxidation;
参考文献
Journal of Organic Chemistry, , vol. 64, # 26 p. 9704 - 9710
反应条件
Novozym 435; potassium tert-butylate; sodium carbonate; [2,3,4,5-Ph4(η5-C4CNH(i-Pr))]Ru(CO)2Cl in toluene T=25°C; 42 h;
参考文献
Choi, Jun Ho; Choi, Yoon Kyung; Kim, Yu Hwan; Park, Eun Sil; Kim, Eun Jung; Kim, Mahn-Joo; Park, Jaiwook
Journal of Organic Chemistry, 2004 , vol. 69, # 6 p. 1972 - 1977
反应条件
alcohol dehydrogenase from Lactobacillus kefir; alcohol dehydrogenase from Rhodococcus ruber DSM 44541; YcnD-oxidoreductase T=30°C; pH=7.5; 3 h; aq. bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantiospecific reaction;
参考文献
Voss, Constance V.; Gruber, Christian C.; Faber, Kurt; Knaus, Tanja; Macheroux, Peter; Kroutil, Wolfgang
Journal of the American Chemical Society, 2008 , vol. 130, # 42 p. 13969 - 13972
反应条件
cis-[Ru(PPh2)(CH2)5PPh2(ampi)Cl2]; potassium hydroxide T=80°C; 0.5 h; Schlenk technique; Reagent/catalystConcentration;
参考文献
Tuerkmen, Hayati
Applied Organometallic Chemistry, 2012 , vol. 26, # 12 p. 731 - 735
反应条件
N-ethyl-N,N-diisopropylamine; (-)-Tetramisole in chloroform-d1 T=0°C; 6 h; Title compound not separated from byproducts;
参考文献
Organic Letters, , vol. 8, # 7 p. 1351 - 1354
反应条件
1: With hydrogen; Ir-chiral phosphine-oxazoline complex in dichloromethane T=20°C; P=22502.3 Torr; 0.5 h; 2: With n-butyllithium in tetrahydrofuran Further stages. Title compound not separated from byproducts.;
参考文献
Organic Letters, , vol. 9, # 9 p. 1659 - 1661
