1,2,3,4-四氢异喹啉-6-醇合成路线 （共 8 条）
反应条件
hydrogen bromide T=120°C; 3 h;
参考文献
Ben-Daniel; Deuther-Conrad; Scheunemann; Steinbach; Brust; Mishani
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 12 p. 6364 - 6370
反应条件
1: With sodium hydroxide in 1,4-dioxane; water T=-5°C; 2: With hydrogenchloride in 1,4-dioxane; water pH=9;
参考文献
WO2009/105715 A1, ;
Page/Page column 24-25 ;
WO 2009/105715 A1
反应条件
1: 50 percent / H2 / 10percent Pd/C / aq. HCl / 30 h / 775.7 - 1810.02 Torr 2: H2O / 20 °C / other 3-hydroxyphenethylamines, other aldehydes; var. pH View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 15 p. 3061 - 3063
反应条件
1: hydrochloric acid; water 2: hydrochloric acid; water / 170 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 56, p. 1769
参考文献
Journal of Organic Chemistry, , vol. 51, # 15 p. 3061 - 3063
反应条件
triethylamine in tetrahydrofuran; water T=20°C;
参考文献
Horiuchi, Takao; Nagata, Motoko; Kitagawa, Mayumi; Akahane, Kouichi; Uoto, Kouichi
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 23 p. 7850 - 7860
反应条件
acetic anhydride; triethylamine in methanol; ethanol; ethyl acetate
参考文献
Hoechst Aktiengesellschaft
Patent: US4717724 A1, 1988 ;
反应条件
1: dimethylformamide
2: p-TsOH*H2O / CH2Cl2
3: aq NaOH / dioxane
View Scheme
参考文献
Heinonen, Petri; Loennberg, Harri
Tetrahedron Letters, 1997 , vol. 38, # 49 p. 8569 - 8572
