5-苯基-3-异恶唑羧酸合成路线 （共 45 条）
反应条件
1: With sodium hydroxide in ethanol; water T=20°C; 0.0833333 h; 2: With hydrogenchloride in ethanol; water pH=3 - 4;
参考文献
Chapal, Nicolas; McNicol, Patricia; Jette, Lucie
Patent: US2006/223884 A1, 2006 ;
Location in patent: Page/Page column 58 ;
反应条件
lithium hydroxide hydrate in tetrahydrofuran T=50°C; 1 h;
参考文献
Veeraswamy; Kurumurthy; Santhosh Kumar; Sambasiva Rao; Thelakkat, Kavya; Kotamraju, Srigiridhar; Narsaiah
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 9 p. 1369 - 1375
反应条件
sodium hydroxide in ethanol
参考文献
EP1216980 A1, ;
EP 1216980 A1
反应条件
potassium hydroxide in ethanol; water Reflux;
参考文献
Potkin; Gadzhily; Dikusar; Petkevich; Zhukovskaya; Aliev; Nagieva
Russian Journal of Organic Chemistry, 2012 , vol. 48, # 1 p. 127 - 136
反应条件
1.1: sodium ethanolate / ethanol / 2 h / Reflux 1.2: 1 h 2.1: hydroxylamine hydrochloride / ethanol / 2 h / Reflux 3.1: sodium hydroxide / ethanol / 24 h / 20 °C 3.2: pH 2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 12 p. 3777 - 3786
反应条件
1.1: hydroxylamine hydrochloride / ethanol / 2 h / Reflux 2.1: sodium hydroxide / ethanol / 24 h / 20 °C 2.2: pH 2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 12 p. 3777 - 3786
反应条件
1: hydroxylamine hydrochloride / methanol / 2 h / 50 °C 2: lithium hydroxide hydrate / tetrahydrofuran / 1 h / 50 °C View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 51, # 9 p. 1369 - 1375
反应条件
1: NH2OH*HCl / aq. ethanol / 8 h / Heating 2: KMnO4 / acetone View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 98, p. 74 - 84
反应条件
1: aq. NaOH 2: KMnO4, aq. H2SO4 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 25, p. 1160 - 1164
反应条件
potassium permanganate in potassium hydroxide
参考文献
Gazzetta Chimica Italiana, , vol. 99, p. 1107 - 1114
