(3S)-3-{[(苄氧基)羰基]氨基}-3-苯丙酸合成路线 （共 20 条）
反应条件
sodium hydroxide in methanol; isopropyl alcohol T=20°C; 2 h; Inert atmosphereLarge scale;
参考文献
Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1094 - 1103
反应条件
dimethylsulfide in dichloromethane; trifluoroacetic acid T=20°C; Hydrolysis; 3 h;
参考文献
Evans, David A.; Wu, Leester D.; Wiener, John J. M.; Johnson, Jeffrey S.; Ripin, David H. B.; Tedrow, Jason S.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6411 - 6417
反应条件
silver benzoate in 1,4-dioxane; water Wolff rearrangement; 0.0166667 h; microwave irradiation;
参考文献
Kantharaju; Suresh Babu, Vommina V.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 10 p. 2152 - 2158
反应条件
1: sodium carbonate / dichloromethane; water / 16 h / 20 °C 2: sodium hydroxide / methanol; water / 16 h / 20 °C View Scheme
参考文献
Abrunhosa-Thomas, Isabelle; Plas, Aurelie; Kandepedu, Nishanth; Chalard, Pierre; Troin, Yves
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 486 - 495
反应条件
sodium hydroxide 0.166667 h;
参考文献
Zemlicka; Bhuta
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 167 - 174
反应条件
1: 89 percent / NaN(SiMe3)2 / tetrahydrofuran / 2 h / -78 °C 2: 89 percent / H2O2; LiOH / tetrahydrofuran; H2O / 1.5 h / 0 °C 3: 74 percent / Et3N; DPPA / toluene / 6.5 h / Heating 4: 91 percent / Me2S / CH2Cl2; trifluoroacetic acid / 3 h / 20 °C View Scheme
参考文献
Evans, David A.; Wu, Leester D.; Wiener, John J. M.; Johnson, Jeffrey S.; Ripin, David H. B.; Tedrow, Jason S.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6411 - 6417
反应条件
1: 74 percent / Et3N; DPPA / toluene / 6.5 h / Heating 2: 91 percent / Me2S / CH2Cl2; trifluoroacetic acid / 3 h / 20 °C View Scheme
参考文献
Evans, David A.; Wu, Leester D.; Wiener, John J. M.; Johnson, Jeffrey S.; Ripin, David H. B.; Tedrow, Jason S.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6411 - 6417
反应条件
1: 89 percent / H2O2; LiOH / tetrahydrofuran; H2O / 1.5 h / 0 °C 2: 74 percent / Et3N; DPPA / toluene / 6.5 h / Heating 3: 91 percent / Me2S / CH2Cl2; trifluoroacetic acid / 3 h / 20 °C View Scheme
参考文献
Evans, David A.; Wu, Leester D.; Wiener, John J. M.; Johnson, Jeffrey S.; Ripin, David H. B.; Tedrow, Jason S.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6411 - 6417
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / |Inert atmosphere 1.2: 2 h / -78 °C / |Inert atmosphere 2.1: hydrogen; palladium hydroxide on carbon / methanol / 144 h / 3102.97 Torr 3.1: sodium carbonate / dichloromethane; water / 16 h / 20 °C 4.1: sodium hydroxide / methanol; water / 16 h / 20 °C View Scheme
参考文献
Abrunhosa-Thomas, Isabelle; Plas, Aurelie; Kandepedu, Nishanth; Chalard, Pierre; Troin, Yves
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 486 - 495
反应条件
1: hydrogen; palladium hydroxide on carbon / methanol / 144 h / 3102.97 Torr 2: sodium carbonate / dichloromethane; water / 16 h / 20 °C 3: sodium hydroxide / methanol; water / 16 h / 20 °C View Scheme
参考文献
Plas, Aurelie; Troin, Yves; Chalard, Pierre; Marchand, Fabien; Eschalier, Alain
European Journal of Organic Chemistry, 2012 , # 30 p. 6070 - 6079,10
Title/Abstract Full Text Show Details
Plas, Aurelie; Marchand, Fabien; Eschalier, Alain; Troin, Yves; Chalard, Pierre
European Journal of Organic Chemistry, 2012 , # 30 p. 6070 - 6079
