1.1: Ti(i-PrO)4; i-PrMgCl / diethyl ether / -35 - 0 °C 1.2: 74 percent / diethyl ether / 2 h / -35 °C 2.1: BBr3 / CH2Cl2 / -78 - -20 °C 3.1: 105 mg / aq. MeNH2; H5IO6 / methanol / 17 h 4.1: 73 percent / H2 / Pd(OH)2/C / methanol / 0.33 h View Scheme

1.1: Ti(i-PrO)4; i-PrMgCl / diethyl ether / -35 - 0 °C 1.2: 74 percent / diethyl ether / 2 h / -35 °C 2.1: BBr3 / CH2Cl2 / -78 - -20 °C 3.1: 105 mg / aq. MeNH2; H5IO6 / methanol / 17 h 4.1: 73 percent / H2 / Pd(OH)2/C / methanol / 0.33 h View Scheme