2-氯-1-吗琳乙-1-酮合成路线 （共 27 条）
反应条件
potassium carbonate in toluene T=60°C; 2 h;
参考文献
CHANG, Zee-Fen; HU, Chun-Mei; FANG, Jim-Min; YEH, Ming-Tyng
Patent: WO2012/72019 A1, 2012 ;
Location in patent: Page/Page column 71-72 ;
WO 2012/072019 A1
反应条件
triethylamine in tetrahydrofuran; chloroacetyl chloride
反应条件
triethylamine in dichloromethane
参考文献
G. D. Searle and Co.
Patent: US5753660 A1, 1998 ;
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in water T=30°C; 2 h;
参考文献
Pielichowski, Jan; Popielarz, Roman
Tetrahedron, 1984 , vol. 40, # 14 p. 2671 - 2676
参考文献
Boehringer Mannheim GmbH
Patent: US6121322 A1, 2000 ;
US 6121322 A
反应条件
1: chloroacetic acid With dicyclohexyl-carbodiimide in dichloromethane T=20°C; 0.5 h; 2: morpholine With 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C;
参考文献
European Journal of Medicinal Chemistry, , vol. 41, # 8 p. 985 - 990
反应条件
in dichloromethane T=-25 - 20°C; 3.5 h;
参考文献
Chemistry of Natural Compounds, , vol. 48, # 6 p. 1047 - 1053
Khim. Prir. Soedin., , vol. 48, # 6 p. 924 - 929,6
参考文献
Farmaco, Edizione Scientifica, , vol. 12, p. 1016,1021
参考文献
Smolinski
Roczniki Chemii, 1956 , vol. 30, p. 1111,1114
Chem.Abstr., 1957 , p. 8755
参考文献
Speziale; Hamm
Journal of the American Chemical Society, 1956 , vol. 78, p. 5580,5582
