2,2,4-三甲基-1,3-戊二醇合成路线 (共 62 条)
反应条件
diethylphosphoric acid ethyl ester; benzene T=250°C;
参考文献
Baltz,H. et al.
Journal fuer Praktische Chemie (Leipzig), 1965 , vol. 29, p. 250 - 258
反应条件
sulfuric acid Heating; Further byproducts given;
参考文献
Mazet,M.; Desmaison-Brut,M.
Bulletin de la Societe Chimique de France, 1971 , p. 2656 - 2662
参考文献
Perry et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 3618
参考文献
Brannock; Lappin
Journal of the American Chemical Society, 1955 , vol. 77, p. 6052
参考文献
Fossek
Monatshefte fuer Chemie, 1883 , vol. 4, p. 671
反应条件
1: TsOH*H2O / CHCl3
2: 500 °C
3: H2 / Raney-Ni / dioxane
View Scheme
参考文献
Schwenk,U.; Becker,A.
Justus Liebigs Annalen der Chemie, 1972 , vol. 756, p. 162 - 169
反应条件
1: benzene; pyridine
2: 500 °C
3: palladium/charcoal / Hydrogenation.Erwaermen des Reaktionsprodukts mit wss.-aethanol.Natronlauge
View Scheme
参考文献
Monsanto Chem.Co.
Patent: US2889354 , 1955 ;
反应条件
1: 2,2,4-trimethyl-1,3-pentanediol With potassium hexamethylsilazane in tetrahydrofuran
T=0°C; 1 h; Inert atmosphere;
2: isobutyraldehyde in tetrahydrofuran
T=55°C; Inert atmosphere; Reagent/catalyst; Overall yield = 92.5 percent; Overall yield = 6.637 g;
参考文献
Toermaekangas, Olli P.; Koskinen, Ari M. P.
Organic Process Research and Development, 2001 , vol. 5, # 4 p. 421 - 425
反应条件
1: 2,2,4-trimethyl-1,3-pentanediol With n-butyllithium in tetrahydrofuran
Inert atmosphere;
2: isobutyraldehyde in tetrahydrofuran
0.533333 h; Inert atmosphere; SolventReagent/catalyst;
参考文献
Toermaekangas, Olli P.; Koskinen, Ari M. P.
Organic Process Research and Development, 2001 , vol. 5, # 4 p. 421 - 425
反应条件
durch wiederholtes abwechselndes Kochen und Entwaessern mit Natriumsulfat;
参考文献
Brauchbar; Kohn
Monatshefte fuer Chemie, 1898 , vol. 19, p. 46