2-甲氧基-4-硝基吡啶 1-氧化物合成路线 （共 10 条）
反应条件
sulfuric acid; nitric acid T=100°C;
参考文献
RESEARCH TRIANGLE INSTITUTE; CARROLL, Frank Ivy; ONDACHI, Pauline Wanjiku
Patent: WO2012/24615 A1, 2012 ;
Location in patent: Page/Page column 56 ;
WO 2012/024615 A1
反应条件
sulfuric acid; nitric acid in sulfuric acid T=90 - 100°C; 3 h;
参考文献
Leznoff; Svirskaya; Yedidia
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 1 p. 145 - 147
反应条件
sulfuric acid; nitric acid T=75°C; 1.5 h;
参考文献
Webber; Bleckman; Attard; Deal; Kathardekar; Welsh; Janson; Matthews; Smith; Freer; Jordan; Bacquet; Howland; Booth; Ward; Hermann; White; Morse; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 733 - 746
反应条件
1: chloroform 2: concentrated sulfuric acid; concentrated nitric acid View Scheme
参考文献
RESEARCH TRIANGLE INSTITUTE; CARROLL, Frank Ivy; ONDACHI, Pauline Wanjiku
Patent: WO2012/24615 A1, 2012 ;
WO 2012/024615 A1
反应条件
sulfuric acid; nitric acid
参考文献
Schnekenburger; Riedel
Archiv der Pharmazie, 1982 , vol. 315, # 10 p. 825 - 831
反应条件
1: 98 percent / Fe; AcOH / 100 °C 2: 43 percent / NaNO2; NaBr; CuSO4 / H2SO4 / 0 °C 3: 100 percent / PdCl2(dppf); KOAc / dimethylformamide / 80 °C View Scheme
参考文献
RESEARCH TRIANGLE INSTITUTE; CARROLL, Frank Ivy; ONDACHI, Pauline Wanjiku
Patent: WO2012/24615 A1, 2012 ;
WO 2012/024615 A1
反应条件
1: 90 percent / Fe / acetic acid 2: NaNO2, 48percent fluoroboric acid / 1) 0 deg, 45 min, 2) 0 deg C - RT, 30 min, 30 - 35 deg C, 30 min 3: 69 percent / iodotrimethylsilane / CH2Cl2 / 1.) RT, 4 h, 2.) 40 deg C, 1 h, RT, overnight View Scheme
参考文献
Leznoff; Svirskaya; Yedidia
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 1 p. 145 - 147
反应条件
1: 90 percent / Fe / acetic acid 2: NaNO2, 48percent fluoroboric acid / 1) 0 deg, 45 min, 2) 0 deg C - RT, 30 min, 30 - 35 deg C, 30 min View Scheme
参考文献
Leznoff; Svirskaya; Yedidia
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 1 p. 145 - 147
反应条件
1: 98 percent / Fe; AcOH / 100 °C 2: 43 percent / NaNO2; NaBr; CuSO4 / H2SO4 / 0 °C View Scheme
参考文献
RESEARCH TRIANGLE INSTITUTE; CARROLL, Frank Ivy; ONDACHI, Pauline Wanjiku
Patent: WO2012/24615 A1, 2012 ;
WO 2012/024615 A1
反应条件
iron; acetic acid T=100°C;
参考文献
Fraley, Mark E; Rubino, Robert S; Hoffman, William F; Hambaugh, Scott R; Arrington, Kenneth L; Hungate, Randall W; Bilodeau, Mark T; Tebben, Andrew J; Rutledge, Ruth Z; Kendall, Richard L; McFall, Rosemary C; Huckle, William R; Coll, Kathleen E; Thomas, Kenneth A
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 24 p. 3537 - 3541
