2-溴-3’,5’-二-叔丁-4’-羟基苯乙酮合成路线 （共 17 条）
反应条件
bromine in ethanol 2.5 h;
参考文献
Zhang, Kai; Corrie, John E. T.; Munasinghe, V. Ranjit N.; Wan, Peter
Journal of the American Chemical Society, 1999 , vol. 121, # 24 p. 5625 - 5632
反应条件
thiourea in ethyl acetate; acetone
参考文献
SANKYO COMPANY, LIMITED
Patent: US2003/134859 A1, 2003 ;
反应条件
sodium hydrogencarbonate in methanol
T=23°C; 72 h;
参考文献
Hershberger, Paul M.; Peddibhotla, Satyamaheshwar; Sessions, E. Hampton; Divlianska, Daniela B.; Correa, Ricardo G.; Pinkerton, Anthony B.; Reed, John C.; Roth, Gregory P.
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 900 - 907
反应条件
in butan-1-ol
T=115°C; 15 h;
参考文献
Peddibhotla, Satyamaheshwar; Shi, Ranxin; Khan, Pasha; Smith, Layton H.; Mangravita-Novo, Arianna; Vicchiarelli, Michael; Su, Ying; Okolotowicz, Karl J.; Cashman, John R.; Reed, John C.; Roth, Gregory P.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 12 p. 4793 - 4797
反应条件
1: sodium azide / H2O; acetone / 1 h / Ambient temperature
2: H2, HCl / Pd-C / methanol
3: 57.8 percent / HCl / H2O; ethanol / 1.5h, r.t., 2h, reflux
4: 39 percent / K2CO3 / acetone / 1 h / Ambient temperature
View Scheme
参考文献
Isomura; Sakamoto; Ito; Homma; Abe; Kubo
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 152 - 165
反应条件
in ethanol; water; acetic acid; ethyl acetate
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US4636516 A1, 1987 ;
反应条件
in ethanol
Ambient temperature;
参考文献
Isomura; Sakamoto; Ito; Homma; Abe; Kubo
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 152 - 165
反应条件
1: 56.7 percent / ethanol / Ambient temperature
2: 73 percent / sodium / methanol / 0.5 h / 0 - 5 °C
View Scheme
参考文献
Isomura; Sakamoto; Ito; Homma; Abe; Kubo
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 152 - 165
反应条件
1: 56.7 percent / ethanol / Ambient temperature
2: 73 percent / sodium / methanol / 0.5 h / 0 - 5 °C
3: 62.5 percent / m-chloroperbenzoic acid, 1,2-dimethoxyethane / Heating
View Scheme
参考文献
Isomura; Sakamoto; Ito; Homma; Abe; Kubo
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 152 - 165
反应条件
1: 56.7 percent / ethanol / Ambient temperature
2: 71.1 percent / sodium / methanol / 0.5 h / 0 - 5 °C
View Scheme
参考文献
Isomura; Sakamoto; Ito; Homma; Abe; Kubo
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 152 - 165
