3,3,5,5-四甲基环己酮合成路线 （共 36 条）
反应条件
1: 84.6 percent / Br2 / acetic acid
2: 84 percent / KOH
3: 70 percent / Br2 / acetic acid
4: 62 percent / 1M NaOH / 110 °C
5: 57 percent / I2, KI
6: 90 percent / P2O5 / neat (no solvent) / 38 °C / 10 Torr
View Scheme
参考文献
Gill, G. Bryon; Idris, Muhammad S. Hj.; Kirollos, Kirollos S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 18 p. 2355 - 2366
反应条件
1: PCl5 / CH2Cl2 / Heating
3: hexane / 24 h / Irradiation
View Scheme
参考文献
McCullough,J.J.; Manning,C.
Journal of Organic Chemistry, 1978 , vol. 43, p. 2839 - 2842
反应条件
1: PCl5 / CH2Cl2 / Heating
3: hexane / 24 h / Irradiation
View Scheme
参考文献
McCullough,J.J.; Manning,C.
Journal of Organic Chemistry, 1978 , vol. 43, p. 2839 - 2842
反应条件
1: 3,3,5,5-tetramethylcyclohexan-1-one With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 1 h;
2: diphenyldisulfane in tetrahydrofuran
T=22°C; 4 h;
参考文献
Billings, Susan B.; Woerpel
Journal of Organic Chemistry, 2006 , vol. 71, # 14 p. 5171 - 5178
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; potassium tert-butylate; oxygen in tert-butyl alcohol
参考文献
Gill, G. Bryon; Idris, Muhammad S. Hj.; Kirollos, Kirollos S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 18 p. 2355 - 2366
反应条件
1: NaH / 1,2-dimethoxy-ethane
2: 59 percent / LDA / tetrahydrofuran; hexane; diethyl ether
3: 66 percent / HCOOH; aq. H3PO4 / toluene / 8 h / 90 °C
View Scheme
参考文献
Kraft, Philip; Cadalbert, Riccardo
Synthesis, 2002 , # 15 p. 2243 - 2253
