(R)-(-)-3-异丙基-2,5-哌嗪二酮合成路线 （共 15 条）
反应条件
1: With triethylamine in tetrahydrofuran; chloroform T=-70°C; 2: in toluene Heating; Further stages.;
参考文献
Li, Xiaoyan; Yin, Wenyuan; Sarma, P.V.V. Srirama; Zhou, Hao; Jun Ma; Cook, James M.
Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8569 - 8573
反应条件
water in N,N-dimethyl-formamide T=150°C; 2.5 h; Microwave irradiation; enantioselective reaction;
参考文献
Coursindel, Thibault; Restouin, Audrey; Dewynter, Georges; Martinez, Jean; Collette, Yves; Parrot, Isabelle
Bioorganic Chemistry, 2010 , vol. 38, # 5 p. 210 - 217
反应条件
in water T=150°C; 0.25 h; microwave irradiation;
参考文献
Carlsson, Anna-Carin; Jam, Fariba; Tullberg, Marcus; Pilotti, Ake; Ioannidis, Panos; Luthman, Kristina; Grotli, Morten
Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5199 - 5201
反应条件
1: 87 percent / N-methylmorpholine, isobutyl chloroformate / tetrahydrofuran; dimethylformamide 2: 1.) H2 / 1.) 10percent Pd/C / 1.) CH3OH, CH2Cl2, 24 h, 2.) toluene, reflux, 12 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 2 p. 157 - 166
反应条件
1: 90 percent 2: 86 percent / DIC; HOBt 3: TFA 4: toluene / Heating View Scheme
参考文献
Synlett, , # 7 p. 1139 - 1141
反应条件
1: 86 percent / DIC; HOBt 2: TFA 3: toluene / Heating View Scheme
参考文献
Synlett, , # 7 p. 1139 - 1141
反应条件
1: TFA 2: toluene / Heating View Scheme
参考文献
Synlett, , # 7 p. 1139 - 1141
反应条件
hydrogen; palladium on activated charcoal 1.) CH3OH, CH2Cl2, 24 h, 2.) toluene, reflux, 12 h; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 2 p. 157 - 166
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran 16 h; Heating / reflux; 2: With sodium hydroxide; water in tetrahydrofuran T=0 - 20°C; 1 h;
参考文献
PANACOS PHARMACEUTICALS, INC.; NITZ, Theodore, J.; SALZWEDEL, Karl; FINNEGAN, Catherine; WILD, Carl; BRUNTON, Shirley; FLANAGAN, Stuart; MONTALBETTI, Christian; COULTER, Thomas, Stephen; KIMBER, Marc; MAGARACI, Filippo; JOHNSTON, David
Patent: WO2008/134035 A1, 2008 ;
Location in patent: Page/Page column 207-208 ;
反应条件
1: 66 percent / CH2Cl2 / 72 h 2: 60 percent / BuLi / hexane; tetrahydrofuran / 10 h / -70 °C 3: 1.) hydrochloric acid, 2.) ammonia / 1.) H2O, room temperature, 16 h, 2.) H2O View Scheme
参考文献
Rose, Janet E.; Leeson, Paul D.; Gani, David
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 2 p. 157 - 166
