N-[3-[1-[(2R,4S,5R)-4-羟基-5-(羟基甲基)四氢呋喃-2-基]咪唑-4-基]苯基]苯甲酰胺合成路线 （共 6 条）
反应条件
1: 1.) NaH / 1.) CH3CN, 0 deg C, 40 min, 2.) CH3CN, 3 h 2: 99 percent / 1percent methanol. NaOH / 1 h / Ambient temperature 3: 99 percent / H2 / 5percent Pd/C / methanol / 2 h / Ambient temperature 4: pyridine / 0.5 h / 0 °C 5: pyridine / 2.5 h / Ambient temperature 6: sat. aq. NH4OH / 1 h / 0 - 20 °C View Scheme
参考文献
Griffin, Linda C.; Kiessling, Laura L.; Beal, Peter A.; Gillespie, Paul; Dervan, Peter B.
Journal of the American Chemical Society, 1992 , vol. 114, # 21 p. 7976 - 7982
反应条件
1: 99 percent / H2 / 5percent Pd/C / methanol / 2 h / Ambient temperature 2: pyridine / 0.5 h / 0 °C 3: pyridine / 2.5 h / Ambient temperature 4: sat. aq. NH4OH / 1 h / 0 - 20 °C View Scheme
参考文献
Griffin, Linda C.; Kiessling, Laura L.; Beal, Peter A.; Gillespie, Paul; Dervan, Peter B.
Journal of the American Chemical Society, 1992 , vol. 114, # 21 p. 7976 - 7982
反应条件
1: 99 percent / 1percent methanol. NaOH / 1 h / Ambient temperature 2: 99 percent / H2 / 5percent Pd/C / methanol / 2 h / Ambient temperature 3: pyridine / 0.5 h / 0 °C 4: pyridine / 2.5 h / Ambient temperature 5: sat. aq. NH4OH / 1 h / 0 - 20 °C View Scheme
参考文献
Griffin, Linda C.; Kiessling, Laura L.; Beal, Peter A.; Gillespie, Paul; Dervan, Peter B.
Journal of the American Chemical Society, 1992 , vol. 114, # 21 p. 7976 - 7982
反应条件
1: 71 percent / 1 h / 190 °C 2: 1.) NaH / 1.) CH3CN, 0 deg C, 40 min, 2.) CH3CN, 3 h 3: 99 percent / 1percent methanol. NaOH / 1 h / Ambient temperature 4: 99 percent / H2 / 5percent Pd/C / methanol / 2 h / Ambient temperature 5: pyridine / 0.5 h / 0 °C 6: pyridine / 2.5 h / Ambient temperature 7: sat. aq. NH4OH / 1 h / 0 - 20 °C View Scheme
参考文献
Griffin, Linda C.; Kiessling, Laura L.; Beal, Peter A.; Gillespie, Paul; Dervan, Peter B.
Journal of the American Chemical Society, 1992 , vol. 114, # 21 p. 7976 - 7982
反应条件
1: 1.) NaH / 1.) CH3CN, 0 deg C, 40 min, 2.) CH3CN, 3 h 2: 99 percent / 1percent methanol. NaOH / 1 h / Ambient temperature 3: 99 percent / H2 / 5percent Pd/C / methanol / 2 h / Ambient temperature 4: pyridine / 0.5 h / 0 °C 5: pyridine / 2.5 h / Ambient temperature 6: sat. aq. NH4OH / 1 h / 0 - 20 °C View Scheme
参考文献
Griffin, Linda C.; Kiessling, Laura L.; Beal, Peter A.; Gillespie, Paul; Dervan, Peter B.
Journal of the American Chemical Society, 1992 , vol. 114, # 21 p. 7976 - 7982
反应条件
1: pyridine / 0.5 h / 0 °C 2: pyridine / 2.5 h / Ambient temperature 3: sat. aq. NH4OH / 1 h / 0 - 20 °C View Scheme
参考文献
Griffin, Linda C.; Kiessling, Laura L.; Beal, Peter A.; Gillespie, Paul; Dervan, Peter B.
Journal of the American Chemical Society, 1992 , vol. 114, # 21 p. 7976 - 7982
