4-苄基-3-[(4-甲氧基苯基)乙酰基]-1,3-恶唑烷-2-酮合成路线 （共 7 条）
反应条件
1: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran T=-78°C; 2: (4-methoxyphenyl)acetyl chloride in tetrahydrofuran T=-78 - 20°C; 3: With ammonium chloride in tetrahydrofuran; water
参考文献
Zeitlmann, Lutz; Niestroj, Andre; Heiser, Ulrich
Patent: US2011/224225 A1, 2011 ;
Location in patent: Page/Page column 22 ;
US 20110224225 A1
反应条件
1: (S)-(-)-4-benzyl-2-oxazolidinone With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.25 h; 2: C14H18O4 in tetrahydrofuran; hexane T=-78 - 20°C; 12.25 h;
参考文献
Wyeth
Patent: US2007/135449 A1, 2007 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1: With triethylamine in toluene T=80°C; 0.166667 h; Inert atmosphere; 2: With pivaloyl chloride in toluene 14 h; Inert atmosphereReflux;
参考文献
Carroll, Vincent M.; Jeyakumar; Carlson, Kathryn E.; Katzenellenbogen, John A.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 1 p. 528 - 537
反应条件
n-butyllithium in tetrahydrofuran; hexane; toluene
参考文献
SmithKline Beechman Corp.
Patent: US5438118 A1, 1995 ;
US 5438118 A
反应条件
1: SOCl2 / 2 h / Heating 2: 237 g / n-BuLi / tetrahydrofuran; hexane / -65 - 20 °C View Scheme
参考文献
Pearson, Anthony J.; Lee, Kieseung
Journal of Organic Chemistry, 1995 , vol. 60, # 22 p. 7153 - 7160
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 30 min; room temp., 20 h; Yield given;
参考文献
Pearson, Anthony J.; Lee, Kieseung
Journal of Organic Chemistry, 1995 , vol. 60, # 22 p. 7153 - 7160
反应条件
1: 167.4 g / NaHMDS / tetrahydrofuran / 0.17 h / cooling 2: 96 percent / LiAlH4 / tetrahydrofuran / 0.25 h / cooling 3: 46 percent / 2-(di-tert-butylphosphino)-1,1'-binaphthyl; Cs2CO3; Pd(OAc)2 / toluene / 22 h / 50 °C View Scheme
参考文献
Heemstra, Jennifer M.; Kerrigan, Sean A.; Doerge, Daniel R.; Helferich, William G.; Boulanger, William A.
Organic Letters, 2006 , vol. 8, # 24 p. 5441 - 5443
