2-羟基亚氨基乙酰乙酸叔丁酯合成路线 （共 6 条）
反应条件
acetic acid; sodium nitrite
参考文献
Pharmacia and Upjohn Company LLC
Patent: US2006/9510 A1, 2006 ;
Location in patent: Page/Page column 15; 17 ;
反应条件
sodium nitrite in acetic acid T=20°C;
参考文献
Sugen, Inc.
Patent: US6878733 B1, 2005 ;
Location in patent: Page/Page column 195 ;
US 6878733 B1
反应条件
1: 2-hydroxyimino-3-oxobutyric acid tert-butyl ester With zinc T=60 - 80°C; 1 h; 2: ethyl acetoacetate T=85°C; 4 h; Heating / reflux;
参考文献
CURIS, INC.
Patent: WO2008/33747 A2, 2008 ;
Location in patent: Page/Page column 200 ;
反应条件
dinitrogen tetraoxide; sodium sulfate in chloroform
参考文献
Dahn,H. et al.
Helvetica Chimica Acta, 1970 , vol. 53, p. 1598 - 1605
反应条件
hydrogen; palladium on activated charcoal in acetic acid
T=65°C; Knorr pyrrole reaction; P=2327.17 Torr; 7 h;
参考文献
Pharmacia and Upjohn Company LLC
Patent: US2006/9510 A1, 2006 ;
Location in patent: Page/Page column 16 ;
反应条件
sodium acetate; acetic acid; zinc in water
T=65°C; 2 h;
参考文献
Smith, Kevin M.; Pandey, Ravindra K.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1383 - 1388
