(R)-(-)-甘油醇缩丙酮合成路线 （共 67 条）
反应条件
1: 85 percent / H2 / palladium black / ethanol / 2 h / Ambient temperature 2: 1.) Pb(OAc)4; 2.) NaBH4 / 1.) ethyl acetate, benzene, 50 deg C, 1 h; 2.) ethanol, room temp., 5 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 572 - 582
反应条件
sodium periodate in dichloromethane; water T=20°C;
参考文献
Journal of Organic Chemistry, , vol. 73, # 3 p. 1040 - 1055
反应条件
n-butyric anhydride; lipase AK in di-isopropyl ether T=0 - 1°C; 25 h; Yields of byproduct given;
参考文献
Vaenttinen, Eero; Kanerva, Liisa T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 23 p. 3459 - 3464
反应条件
1: 85 percent / Pb(OAc)4 / benzene; methanol / 0.5 h / 50 °C 2: 95 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 40 p. 4757 - 4758
反应条件
lithium hydroxide hydrate in tetrahydrofuran; water T=20°C; 12 h;
参考文献
European Journal of Organic Chemistry, , # 20 p. 4311 - 4318
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C;
参考文献
Tetrahedron Letters, , vol. 30, # 39 p. 5319 - 5322
反应条件
1: NaIO4 / (nBu)4NBr / CH2Cl2; H2O / 0.5 h / Ambient temperature 2: NaBH4 / methanol / 0.5 h / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 40 p. 4757 - 4758
反应条件
lithium hydroxide hydrate in tetrahydrofuran; water T=20°C; 12 h;
参考文献
European Journal of Organic Chemistry, , # 20 p. 4311 - 4318
反应条件
sodium tetrahydroborate; sodium hydrogencarbonate; BaCl2 1.) H2O, O deg C, 20 min, 2.) 24 h, room temp.; Yield given. Multistep reaction;
参考文献
Synthesis, , # 2 p. 207 - 208
反应条件
phosphate buffer; Lipase Amano PS in 1,4-dioxane T=30°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 6 p. 817 - 819
