(6R,7R)-7-[[1-(4-溴苯基)环戊烷羰基]氨基]-3-甲基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸钠合成路线 （共 4 条）
反应条件
sodium hydrogencarbonate in water; acetone T=0 - 20°C; 6 h;
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Akopyan, S. G.; Grigoryan, M. M.; Ter-Zakharyan, Yu. Z.; et al.
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 2 p. 169 - 173
Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 2 p. 54 - 56
反应条件
1: 1.) NaOH / 1.) 45 deg C, 2.) 120 deg C, 12 h 2: 60.4 percent / KOH / various solvent(s) / 12 h / Heating 3: 1.) triethylamine, chlorocarbonic acid ethyl ester, 2.) NaHCO3 / 1.) acetone, from 0 deg C, 30 min, to RT, 2 h, 2.) acetone, water, 4 h View Scheme
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Akopyan, S. G.; Grigoryan, M. M.; Ter-Zakharyan, Yu. Z.; et al.
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 2 p. 169 - 173
Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 2 p. 54 - 56
反应条件
1: 60.4 percent / KOH / various solvent(s) / 12 h / Heating 2: 1.) triethylamine, chlorocarbonic acid ethyl ester, 2.) NaHCO3 / 1.) acetone, from 0 deg C, 30 min, to RT, 2 h, 2.) acetone, water, 4 h View Scheme
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Akopyan, S. G.; Grigoryan, M. M.; Ter-Zakharyan, Yu. Z.; et al.
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 2 p. 169 - 173
Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 2 p. 54 - 56
反应条件
chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine 1.) acetone, from 0 deg C, 30 min, to RT, 2 h, 2.) acetone, water, 4 h; Yield given. Multistep reaction;
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Akopyan, S. G.; Grigoryan, M. M.; Ter-Zakharyan, Yu. Z.; et al.
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 2 p. 169 - 173
Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 2 p. 54 - 56
