1-(1-萘)-1H-四唑e-5-硫醇合成路线 （共 5 条）
反应条件
1: With sodium azide in ethanol T=79°C; 2 h; 2: With hydrogenchloride in ethanol; water T=20°C;
参考文献
ARDEA BIOSCIENCES, INC.; DE LA ROSA, Martha; GIRARDET, Jean-Luc
Patent: WO2010/135530 A2, 2010 ;
Location in patent: Page/Page column 65 ;
WO 2010/135530 A2
反应条件
sodium hydroxide in water 0.5 h; Heating;
参考文献
Cowper; Astik; Thaker
Journal of the Indian Chemical Society, 1981 , vol. 58, # 11 p. 1087 - 1088
反应条件
1: liq. NH3 / -30 °C 2: hydrazine hydrate, sodium chloroacetate / aq. ethanol 3: sodium nitrate, hydrochloric acid / H2O / 0.67 h / 10 - 15 °C 4: sodium hydroxide / H2O / 0.5 h / Heating View Scheme
参考文献
Cowper; Astik; Thaker
Journal of the Indian Chemical Society, 1981 , vol. 58, # 11 p. 1087 - 1088
反应条件
1: hydrazine hydrate, sodium chloroacetate / aq. ethanol 2: sodium nitrate, hydrochloric acid / H2O / 0.67 h / 10 - 15 °C 3: sodium hydroxide / H2O / 0.5 h / Heating View Scheme
参考文献
Cowper; Astik; Thaker
Journal of the Indian Chemical Society, 1981 , vol. 58, # 11 p. 1087 - 1088
反应条件
1: sodium nitrate, hydrochloric acid / H2O / 0.67 h / 10 - 15 °C 2: sodium hydroxide / H2O / 0.5 h / Heating View Scheme
参考文献
Cowper; Astik; Thaker
Journal of the Indian Chemical Society, 1981 , vol. 58, # 11 p. 1087 - 1088
