8-氟-3,4-二氢-1H-喹啉-2-酮合成路线 （共 4 条）
反应条件
AlCl3, aluminium chloride T=160°C; 1.5 h;
参考文献
MADDAFORD, Shawn; RAMNAUTH, Jailall; RAKHIT, Suman; PATMAN, Joanne; ANNEDI, Subhash C.; ANDREWS, John; DOVE, Peter; SILVERMAN, Sarah; Renton, Paul
Patent: US2008/234237 A1, 2008 ;
Location in patent: Page/Page column 74 ;
US 20080234237 A1
反应条件
1.1: dichloromethane / 2 h / 0 - 20 °C 2.1: AlCl3, aluminium chloride / 5 h / 120 °C 2.2: 20 °C / Cooling with ice View Scheme
参考文献
WO2012/148808 A1, ;
WO 2012/148808 A1
反应条件
1.1: AlCl3, aluminium chloride / carbon disulfide / 4 h / 0 - 100 °C 2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 18 h / 20 °C / |Reflux 3.1: sodium hydroxide; methanol / 20 °C 3.2: pH 1 View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; King, Dalton; Macor, John E.; Olson, Richard E.; Iwuagwu, Christiana I.; Karageorge, George N.
Patent: US2013/79338 A1, 2013 ;
US 20130079338 A1
反应条件
sulfuric acid; nitric acid in water
T=-5°C; 0.333333 - 0.666667 h; Product distribution / selectivity;
参考文献
MADDAFORD, Shawn; RAMNAUTH, Jailall; RAKHIT, Suman; PATMAN, Joanne; ANNEDI, Subhash C.; ANDREWS, John; DOVE, Peter; SILVERMAN, Sarah; Renton, Paul
Patent: US2008/234237 A1, 2008 ;
Location in patent: Page/Page column 87; 91 ;
US 20080234237 A1
