4-氨基-3-硝基苯乙酮合成路线 （共 14 条）
反应条件
1: acetic acid; bromine 2: KHSO3; anhydrous nitric acid / 0 °C / Erhitzen des auf Eis gegossenen Reaktionsgemisches mit Aethanol und CuSO4 auf dem Dampfbad View Scheme
参考文献
Raadsveld
Recueil des Travaux Chimiques des Pays-Bas, 1935 , vol. 54, p. 813,824
反应条件
ethanol; sulfuric acid
参考文献
Raadsveld
Recueil des Travaux Chimiques des Pays-Bas, 1935 , vol. 54, p. 813,824
反应条件
(i) HNO3, (ii) aq. HCl; Multistep reaction;
参考文献
Mann; Back; Mutschler
Archiv der Pharmazie, 1973 , vol. 306, # 8 p. 625 - 631
反应条件
hydrogenchloride
0.5 h; Heating;
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
zinc
T=70 - 72°C; Friedel-Crafts acylation; 0.00416667 h; microwave irradiation;
参考文献
Paul, Satya; Nanda, Puja; Gupta, Rajive; Loupy, Andre
Synthesis, 2003 , # 18 p. 2877 - 2881
反应条件
sodium ethanolate in ethanol
T=0 - 5°C;
参考文献
Bertelli, Lucia; Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Manera, Clementina; Scartoni, Valerio; Martini, Claudia; Giannaccini, Gino; Trincavelli, Letizia; Barili, Pier Luigi
Farmaco, 1998 , vol. 53, # 4 p. 305 - 311
反应条件
ammonia in ethanol
T=100°C; Sealed tube;
参考文献
Vitale, Gabriella; Corona, Paola; Loriga, Mario; Carta, Antonio; Paglietti, Giuseppe; Giliberti, Gabriele; Sanna, Giuseppina; Farci, Pamela; Marongiu, Maria Elena; La Colla, Paolo
European Journal of Medicinal Chemistry, 2012 , vol. 53, p. 83 - 97
反应条件
1: 1 h / 30 °C
2: nitric acid / 1 h / 5 °C
3: hydrogenchloride / 4 h / |Reflux
View Scheme
参考文献
Blau, Lorena; Menegon, Renato Farina; Trossini, Gustavo H. G.; Molino, Joao Vitor Dutra; Vital, Drielli Gomes; Cicarelli, Regina Maria Barretto; Passerini, Gabriela Duo; Bosquesi, Priscila Longhin; Chin, Chung Man
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 142 - 151
参考文献
Borsche; Barthenheier
Justus Liebigs Annalen der Chemie, 1942 , vol. 553, p. 250,257
参考文献
Mayer; Stark; Schoen
Chemische Berichte, 1932 , vol. 65, p. 1333,1335
