2'-脱氧-2',2'-二氟尿苷 3',5'-二苯甲酸酯合成路线 （共 6 条）
反应条件
acetic acid in water 14 h; Reflux;
参考文献
ALIOS BIOPHARMA, INC.; Beigelman, Leonid; Wang, Guangyi; Smith, David Bernard; Deval, Jerome; Prhavc, Marija
Patent: US2013/165400 A1, 2013 ;
Location in patent: Paragraph 0418; 0419 ;
反应条件
1: [131I]-Uracil With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane T=135 - 140°C; 5 - 6 h; 2: 21-deoxy-21,21-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate With trimethylsilyl trifluoromethanesulfonate in acetonitrile 3: With water in dichloromethane; acetonitrile
参考文献
DABUR PHARMA LIMITED
Patent: WO2006/92808 A1, 2006 ;
Location in patent: Page/Page column 44; 45 ;
反应条件
tin(IV) chloride in 1,2-dichloro-ethane T=20 - 83°C; 22 h; Product distribution / selectivity;
参考文献
SICOR INC.
Patent: WO2006/63105 A1, 2006 ;
Location in patent: Page/Page column 11-12 ;
反应条件
trimethylsilyl trifluoromethanesulfonate in 1,2-dichloro-ethane T=83°C; 17 h; Product distribution / selectivity;
参考文献
Chou; Heath; Patterson; Poteet; Lakin; Hunt
Synthesis, 1992 , # 6 p. 565 - 570
反应条件
1: pyridine / 15 h / 25 °C 2: acetic acid / water / 14 h / |Reflux View Scheme
参考文献
ALIOS BIOPHARMA, INC.; Beigelman, Leonid; Wang, Guangyi; Smith, David Bernard; Deval, Jerome; Prhavc, Marija
Patent: US2013/165400 A1, 2013 ;
反应条件
ammonia in methanol T=20°C; 15 h;
参考文献
ALIOS BIOPHARMA, INC.; Beigelman, Leonid; Wang, Guangyi; Smith, David Bernard; Deval, Jerome; Prhavc, Marija
Patent: US2013/165400 A1, 2013 ;
Location in patent: Paragraph 0420; 0421 ;
