N-[4-氟-2-硝基-5-(三氟甲基)苯基]乙酰胺合成路线 （共 5 条）
反应条件
nitric acid T=0°C; 0.5 h;
参考文献
Takano, Yasuo; Shiga, Futoshi; Asano, Jun; Hori, Wataru; Fukuchi, Kazunori; Anraku, Tsuyoshi; Uno, Takashi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 3 p. 776 - 792
反应条件
nitric acid T=0°C; 1 h;
参考文献
Ohmori; Sakamoto; Kubota; Shimizu-Sasamata; Okada; Kawasaki; Hidaka; Togami; Furuya; Murase
Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 467 - 475
反应条件
1: hydrogen; AcOH / Pd/C 2: 116 g / Et3N / CHCl3 / 48 h 3: 87 percent / fuming HNO3 / 0.5 h / 0 °C View Scheme
参考文献
Ohmori; Sakamoto; Kubota; Shimizu-Sasamata; Okada; Kawasaki; Hidaka; Togami; Furuya; Murase
Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 467 - 475
反应条件
1: 116 g / Et3N / CHCl3 / 48 h 2: 87 percent / fuming HNO3 / 0.5 h / 0 °C View Scheme
参考文献
Ohmori; Sakamoto; Kubota; Shimizu-Sasamata; Okada; Kawasaki; Hidaka; Togami; Furuya; Murase
Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 467 - 475
反应条件
in hydrogenchloride; ethanol
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
