2-氯-N-(2-(3,4-二甲氧基苯基)乙基)乙酰胺合成路线 （共 5 条）
参考文献
Cho, Su-Dong; Song, Sang-Yong; Park, Yong-Dae; Kim, Jeum-Jong; Joo, Woo-Hong; Shiro, Motoo; Falck; Shin, Dong-Soo; Yoon, Yong-Jin
Tetrahedron Letters, 2003 , vol. 44, # 50 p. 8995 - 8998
反应条件
1: 2-(3,4-dimethoxyphenyl)-ethylamine; 4-formyl-3,5-dimethoxyphenoxy-Merrifield resin With sodium tris(acetoxy)borohydride in acetic acid; N,N-dimethyl-formamide T=20°C; Solid phase reaction; reductive amination; 69 h; 2: chloroacetic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide T=20°C; Solid phase reaction; acylation; 15 h; 3: With dimethylsulfide; water; trifluoroacetic acid in dichloromethane T=20°C; Solid phase reaction; cleavage of amide; 15 h;
参考文献
Pegurier, C.Ecile; Curtet, Sophie; Nicolas, Jean-Paul; Boutin, Jean A.; Delagrange, Philippe; Renard, Pierre; Langlois, Michel
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 1 p. 163 - 171
反应条件
sodium hydroxide; tetra-(n-butyl)ammonium iodide in benzene 1 h; Heating;
参考文献
Ivanov, P. Yu.; Akalaeva, T. V.; Bokanov, A. I.; Shvedov, V. I.
Journal of Organic Chemistry USSR (English Translation), 1986 , p. 1001 - 1002
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 5 p. 1114 - 1115
反应条件
in benzene 10 h; Ambient temperatureIrradiation;
参考文献
Heterocycles, , vol. 41, # 5 p. 959 - 972
反应条件
1.1: sodium periodate
2.1: sodium hydride / 0.02 h
2.2: 25 °C
3.1: lithium aluminum hydride / tetrahydrofuran / 3 h / Heating
4.1: toluene / 1 h / Heating
View Scheme
参考文献
Huang, Chang-Gin; Chang, Bo-Rui; Chang, Nein-Chen
Tetrahedron Letters, 2002 , vol. 43, # 15 p. 2721 - 2723
