反应条件
1: 5,6,7,8-tetrahydro-2H-cycloheptapyrazol-4-one With potassium carbonate; p-methoxybenzyl chloride in acetonitrile T=60°C; 2 h; Inert atmosphere; 2: With copper(ll) bromide in ethyl acetate 1 h; RefluxInert atmosphere; 3: N-(2-Pyridinyl)thiourea Further stages;
参考文献
Hong, Sang-Phyo; Liu, Kevin G.; Ma, Gil; Sabio, Michael; Uberti, Michelle A.; Bacolod, Maria D.; Peterson, John; Zou, Zack Z.; Robichaud, Albert J.; Doller, Dario
Journal of Medicinal Chemistry, 2011 , vol. 54, # 14 p. 5070 - 5081