3,4-二羟基噻吩-2,5-二羧酸二乙基酯二钠盐合成路线 （共 6 条）
反应条件
ethanol; sodium ethanolate T=20°C; 3.5 h; Reflux;
参考文献
Zhang, Hua; Qian, Chao; Chen, Xin-Zhi
Journal of Chemical Research, 2011 , vol. 35, # 6 p. 339 - 340
反应条件
Williamson reaction;
参考文献
Molcanov, Kresimir; Stolic, Ivana; Kovacevic, Goran; Kojic-Prodic, Biserka; Bajic, Miroslav
Journal of Molecular Structure, 2011 , vol. 987, # 1-3 p. 174 - 179
反应条件
sodium hydride; triethylamine in N,N-dimethyl-formamide Williamson synthesis; 5 h; Reflux;
参考文献
Zhang, Hua; Qian, Chao; Chen, Xin-Zhi
Journal of Chemical Research, 2011 , vol. 35, # 6 p. 339 - 340
反应条件
hydrogenchloride in water
参考文献
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Patent: WO2008/106194 A1, 2008 ;
Location in patent: Page/Page column 7-9 ;
反应条件
1.1: sodium hydride; triethylamine / N,N-dimethyl-formamide / 5 h / Reflux 2.1: sodium hydroxide / water / 2 h / Reflux 2.2: 10 °C / pH < 3 View Scheme
参考文献
Zhang, Hua; Qian, Chao; Chen, Xin-Zhi
Journal of Chemical Research, 2011 , vol. 35, # 6 p. 339 - 340
反应条件
1: 0.5 h / Heating
2: 74 percent / aq. NaOH / 1 h / Heating
View Scheme
参考文献
Halfpenny; Rooney; Sloman
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 20 p. 2595 - 2603
