3-羟甲基氮杂环丁烷-1-羧酸叔丁酯合成路线 （共 15 条）
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane T=-78 - 20°C;
参考文献
WO2010/80357 A1, ;
Page/Page column 45-46 ;
WO 2010/080357 A1
反应条件
hydrogenchloride; dimethyl sulfoxide; triethylamine in n-heptane; dichloromethane; ethyl acetate
反应条件
PS-PPh3 in tetrachloromethane; dichloromethane
参考文献
Miller, John F.; Turner, Elizabeth M.; Gudmundsson, Kristjan S.; Jenkinson, Stephen; Spaltenstein, Andrew; Thomson, Michael; Wheelan, Pat
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 7 p. 2125 - 2128
反应条件
1,4-diaza-bicyclo[2.2.2]octane in dichloromethane
T=0°C; 0.25 h;
参考文献
Shanghai Yingli Science And Technology Co., Ltd; Shanghai Pharmvally Innovation Institution Of Biomedicine; Shanghai Chempartner Co., Ltd; XU, Zusheng; QIAN, Su
Patent: EP2676965 A1, 2013 ;
Location in patent: Paragraph 0120; 0121 ;
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0°C; 1 h;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP1961750 A1, 2008 ;
Location in patent: Page/Page column 90 ;
