1-乙酰基-三-苄氧基-罗伯糖合成路线 （共 26 条）
反应条件
1.1: hexamethyldisilazane / toluene / 3 h / Heating 1.2: 91 percent / TMS-triflate / 1,2-dichloro-ethane / 8 h / 20 °C 2.1: 92 percent / NH3 / methanol / 20 °C View Scheme
参考文献
Ghosh, Avik K.; Schuster, Gary B.
Journal of the American Chemical Society, 2006 , vol. 128, # 13 p. 4172 - 4173
反应条件
1: 45 percent / SnCl4 / nitromethane / 3 h / 60 °C 2: 75 percent / NaOMe / methanol / Ambient temperature; pH 13 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 10 p. 2750 - 2755
反应条件
1: 1.) HMDS, (NH4)2SO4, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) pyridine, reflux, 4 h, 2.) acetonitrile, RT, 16 h 2: 46 percent / tert-butyl nitrite / tetrahydrofuran / 50 - 60 °C 3: 57 percent / ammonia / methanol / 14 h / 90 °C View Scheme
参考文献
Nagahara; Anderson; Kini; Dalley; Larson; Smee; Jin; Sharma; Jolley; Robins; Cottam
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 407 - 415
反应条件
chloro-trimethyl-silane; trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane in acetonitrile 2.5 h; Heating;
参考文献
Yadav, Vikas; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Guarcello, Vincenzo; Naguib, Fardos N. M.; El Kouni, Mahmoud H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1987 - 1996
反应条件
1: 14.36 g / trimethylsilyl chloride; hexamethyldisilazane; tin(IV) chloride / acetonitrile / 1.5 h / Heating 2: 5.76 g / sodium methoxide / methanol / 20 °C View Scheme
参考文献
Organic Letters, , vol. 9, # 5 p. 749 - 752
反应条件
1.1: HMDS; (NH4)2SO4 / Heating 1.2: 83 percent / TMSOTf / 1,2-dichloro-ethane 2.1: 85 percent / I2; CH2I2; isoamyl nitrite / CuI / Heating 3.1: 83 percent / NH3 / methanol 4.1: camphorsulfonic acid View Scheme
参考文献
Lee, Jeewoo; Kim, Sung Eun; Lee, Ji Young; Kim, Su Yeon; Kang, Sang Uk; Seo, Seung Hwan; Chun, Moon Woo; Kang, Taehee; Choi, Soo Young; Kim, Hea Ok
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1087 - 1092
反应条件
1: 1) 1,1,1,3,3,3-hexamethyldisilazane, (NH4)2SO4, pyridine, 2) TMS-triflate / 1) 3 h, reflux, 2) 1,2-dichloroethane, 6 h, r.t. 2: 88 percent / NH3 / methanol / 18 h / Ambient temperature View Scheme
参考文献
Rao; Revankar; Vinayak; Robins
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 7 p. 1779 - 1788
反应条件
boron trifluoride diethyl etherate in dichloromethane T=20°C; 2 h;
参考文献
Chemical Communications, , # 25 p. 2720 - 2721
反应条件
1: 14.36 g / trimethylsilyl chloride; hexamethyldisilazane; tin(IV) chloride / acetonitrile / 1.5 h / Heating 2: 5.76 g / sodium methoxide / methanol / 20 °C 3: diphenyl carbonate; sodium hydrogen carbonate / dimethylformamide / 1.5 h / Heating View Scheme
参考文献
Sheng, Jia; Jiang, Jiansheng; Salon, Jozef; Huang, Zhen
Organic Letters, 2007 , vol. 9, # 5 p. 749 - 752
反应条件
1: 68 percent / BF3*Et2O / CHCl3 / 5 h / 20 °C 2: 96 percent / Hg(OCOCF3)2 / acetone; H2O / 6 h / 20 °C 3: m-CPBA / CHCl3 / 12 h / 20 °C 4: 46 percent / SnCl4 / CHCl3 / 5 h / 20 °C View Scheme
参考文献
Mereyala, Hari Babu; Mamidyala, Sreeman Kumar
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 4 p. 655 - 669
