1-乙酰基-三-苄氧基-罗伯糖合成路线 （共 26 条）
反应条件
boron trifluoride diethyl etherate in acetonitrile 48 h; Ambient temperature; Further byproducts given. Yields of byproduct given;
参考文献
Chavis; Grodenic; Imbach
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 219 - 227
反应条件
boron trifluoride diethyl etherate in acetonitrile 3 h; Ambient temperature; Further byproducts given;
参考文献
European Journal of Medicinal Chemistry, , vol. 16, # 3 p. 219 - 227
反应条件
boron trifluoride diethyl etherate in acetonitrile 48 h; Ambient temperature; Further byproducts given. Yields of byproduct given;
参考文献
Chavis; Grodenic; Imbach
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 3 p. 219 - 227
反应条件
boron trifluoride diethyl etherate in acetonitrile 96 h; Ambient temperature; Yield given. Further byproducts given. Yields of byproduct given;
参考文献
European Journal of Medicinal Chemistry, , vol. 16, # 3 p. 219 - 227
反应条件
1.1: HMDS; (NH4)2SO4 / Heating 1.2: 83 percent / TMSOTf / 1,2-dichloro-ethane 2.1: 85 percent / I2; CH2I2; isoamyl nitrite / CuI / Heating 3.1: 83 percent / NH3 / methanol View Scheme
参考文献
Lee, Jeewoo; Kim, Sung Eun; Lee, Ji Young; Kim, Su Yeon; Kang, Sang Uk; Seo, Seung Hwan; Chun, Moon Woo; Kang, Taehee; Choi, Soo Young; Kim, Hea Ok
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1087 - 1092
反应条件
1: 70 percent / SnCl4 / 1,2-dichloro-ethane 2: 81 percent / NH3 / methanol / 20 °C 3: 60 percent / sodium azide / dimethylformamide / 12 h / 110 - 120 °C View Scheme
参考文献
Wang, Peiyuan; Hollecker, Laurent; Pankiewicz, Krzysztof W.; Patterson, Steven E.; Whitaker, Tony; McBrayer, Tamara R.; Tharnish, Phillip M.; Stuyver, Lieven J.; Schinazi, Raymond F.; Otto, Michael J.; Watanabe, Kyoichi A.
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 957 - 960
反应条件
1.1: 94 percent / hexamethyldisilazane; Me3SiCl; trimethylsilyl triflate / acetonitrile / 2.5 h / Heating 2.1: 36 percent / NH3 / methanol / 20 °C 3.1: trityl resin; pyridine / 48 h 3.2: Et3N / methanol / 5 h / 55 °C 3.3: 94 percent / triisopropylsilane; trifluoroacetic acid / CH2Cl2 / 0.17 h View Scheme
参考文献
Yadav, Vikas; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Guarcello, Vincenzo; Naguib, Fardos N. M.; El Kouni, Mahmoud H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1987 - 1996
反应条件
1: 14.36 g / trimethylsilyl chloride, hexamethyldisilazane, trifluoromethanesulfonic acid / acetonitrile / 1 h / Heating 2: sodium methoxide / methanol / Ambient temperature; overnight 3: 2.) Zn/Cu / 1.) acetonitrile, reflux, 2 h, 2.) DMF, RT, 20 h 4: 87 percent / sodium methoxide / methanol / 2 h / Ambient temperature View Scheme
参考文献
Mansuri; Starrett Jr.; Wos; Tortolani; Brodfuehrer; Howell; Martin
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4780 - 4785
反应条件
1: 94 percent / hexamethyldisilazane; Me3SiCl; trimethylsilyl triflate / acetonitrile / 2.5 h / Heating 2: 36 percent / NH3 / methanol / 20 °C View Scheme
参考文献
Yadav, Vikas; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Guarcello, Vincenzo; Naguib, Fardos N. M.; El Kouni, Mahmoud H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1987 - 1996
反应条件
1: 5-aza-cytosine With N,O-bis(trimethylsilyl) trifluoroacetamide in dichloromethane 1.5 h; Reflux; 2: 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose With trimethylsilyl trifluoromethanesulfonate in dichloromethane 2.16667 h; Reflux; 3: With methanol; sodium methylate T=50°C; 1 h;
参考文献
CHEMI SPA
Patent: US2011/245485 A1, 2011 ;
Location in patent: Page/Page column 6 ;
