(2S,3S,4R,5R)-5-(6-氨基-2-己-1-炔基嘌呤-9-基)-3,4-二羟基四氢呋喃-2-甲酰胺合成路线 （共 6 条）
反应条件
trifluoroacetic acid 2 h; Ambient temperature;
参考文献
Homma, Hiroshi; Watanabe, Yohko; Abiru, Toichi; Murayama, Toshihiko; Nomura, Yasuharu; Matsuda, Akira
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2881 - 2890
反应条件
1: 96 percent / 4 h / Ambient temperature 2: NaIO4, Ru2O / acetonitrile; CHCl3; H2O / Ambient temperature 3: 78 percent / thionyl chloride / methanol / 2 h / Ambient temperature 4: 99 percent / bis(triphenylphosphine)palladium dichloride, CuI, Et3N / dimethylformamide / 2 h / 70 °C 5: 80 percent / NH3 / methanol / 3 h / 80 °C 6: 96 percent / 80percent aq. TFA / 2 h / Ambient temperature View Scheme
参考文献
Homma, Hiroshi; Watanabe, Yohko; Abiru, Toichi; Murayama, Toshihiko; Nomura, Yasuharu; Matsuda, Akira
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2881 - 2890
反应条件
1: NaIO4, Ru2O / acetonitrile; CHCl3; H2O / Ambient temperature 2: 78 percent / thionyl chloride / methanol / 2 h / Ambient temperature 3: 99 percent / bis(triphenylphosphine)palladium dichloride, CuI, Et3N / dimethylformamide / 2 h / 70 °C 4: 80 percent / NH3 / methanol / 3 h / 80 °C 5: 96 percent / 80percent aq. TFA / 2 h / Ambient temperature View Scheme
参考文献
Homma, Hiroshi; Watanabe, Yohko; Abiru, Toichi; Murayama, Toshihiko; Nomura, Yasuharu; Matsuda, Akira
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2881 - 2890
反应条件
1: 78 percent / thionyl chloride / methanol / 2 h / Ambient temperature 2: 99 percent / bis(triphenylphosphine)palladium dichloride, CuI, Et3N / dimethylformamide / 2 h / 70 °C 3: 80 percent / NH3 / methanol / 3 h / 80 °C 4: 96 percent / 80percent aq. TFA / 2 h / Ambient temperature View Scheme
参考文献
Homma, Hiroshi; Watanabe, Yohko; Abiru, Toichi; Murayama, Toshihiko; Nomura, Yasuharu; Matsuda, Akira
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2881 - 2890
反应条件
1: 99 percent / bis(triphenylphosphine)palladium dichloride, CuI, Et3N / dimethylformamide / 2 h / 70 °C 2: 80 percent / NH3 / methanol / 3 h / 80 °C 3: 96 percent / 80percent aq. TFA / 2 h / Ambient temperature View Scheme
参考文献
Homma, Hiroshi; Watanabe, Yohko; Abiru, Toichi; Murayama, Toshihiko; Nomura, Yasuharu; Matsuda, Akira
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2881 - 2890
反应条件
1: 80 percent / NH3 / methanol / 3 h / 80 °C 2: 96 percent / 80percent aq. TFA / 2 h / Ambient temperature View Scheme
参考文献
Homma, Hiroshi; Watanabe, Yohko; Abiru, Toichi; Murayama, Toshihiko; Nomura, Yasuharu; Matsuda, Akira
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2881 - 2890
