5-氯-1-苯基-1H-四唑合成路线 （共 21 条）
反应条件
1: 79 percent / HNO3 / 0.08 h / 100 °C 2: 0.15 g / sodium phosphinate / Pd-C / H2O; toluene / 2 h / Heating View Scheme
参考文献
Cristiano, M. Lurdes S.; Johnstone, Robert A. W.
Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 3 p. 489 - 494
反应条件
1: 67 percent / sodium hydride / various solvent(s); tetrahydrofuran / 20 °C 2: 100 percent / 2 h / 150 °C View Scheme
参考文献
Cristiano, M. Lurdes S.; Johnstone, Robert A. W.
Journal of Chemical Research, Synopses, 1997 , # 3 p. 164 - 165
反应条件
potassium tert-butylate in tetrahydrofuran 1.) 5 min, 2.) 60 deg C, 3 h;
参考文献
Cristiano, M. Lurdes S.; Johnstone, Robert A. W.; Price, Peter J.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 12 p. 1453 - 1459
反应条件
1: 80 percent / sodium hydride / various solvent(s); tetrahydrofuran / 20 °C 2: 100 percent / 3 h / 150 °C View Scheme
参考文献
Cristiano, M. Lurdes S.; Johnstone, Robert A. W.
Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 3 p. 489 - 494
反应条件
in acetonitrile
T=0°C; 5 h;
参考文献
Quast, Helmut; Fuss, Andreas; Nahr, Uwe
Chemische Berichte, 1985 , vol. 118, # 6 p. 2164 - 2185
反应条件
sodium hydride in tetrahydrofuran
0.25 h; Ambient temperature;
参考文献
Granchelli, Felix E.; Filer, Crist N.; Soloway, Albert H.; Neumeyer, John L.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2275 - 2278
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate in toluene
T=100°C; Suzuki-Miyaura reaction; 24 h;
参考文献
Walker, Shawn D.; Barder, Timothy E.; Martinelli, Joseph R.; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2004 , vol. 43, # 14 p. 1871 - 1876
反应条件
1: 1.) potassium t-butoxide; 2.) conc. HCl / 1.) dimethyl sulphoxide, 10 min, room temp.; 2.) 75 degC, 2 h
2: 1.5 g / diethyl ether / 1.5 h / Ambient temperature
View Scheme
参考文献
Johnstone, Robert A. W.; Price, Peter J.
Tetrahedron, 1985 , vol. 41, # 12 p. 2493 - 2502
反应条件
1: 95 percent / KOtBu / dimethylformamide / r.t., 3 h then 65 deg C, 24 h
2: H2 / 10percent Pd/C / toluene / 5 h / 40 - 45 °C / 2052 - 2280 Torr
View Scheme
参考文献
Winkel, C.; Aarts, M. W. M. M.; Heide, F. R. van der; Buitenhuis, E. G.; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1989 , vol. 108, # 4 p. 139 - 146
参考文献
Gupton, John T.; Idoux, John P; Baker, Graeme; Colon, Cesar; Crews, A.Donald; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 17 p. 2933 - 2936
