3,5-二叔丁基-4-羟基苯甲酸合成路线 （共 48 条）
反应条件
potassium hydroxide in acetone T=20°C; 18 h;
参考文献
Galemmo, JR., Robert; Holland, Richard; Hum, Gabriel; Pajouhesh, Hossein; Chahal, Navjot; Seid-Bagherzadeh, Mehran; Girard, Amy
Patent: US2009/270394 A1, 2009 ;
Location in patent: Page/Page column 9 ;
US 20090270394 A1
反应条件
nitric acid in acetic acid
参考文献
Zlobina,G.A.; Ershov,V.V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1964 , p. 1570 - 1577
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1964 , # 9 p. 1666 - 1675
反应条件
1,1'-carbonyldiimidazole in tetrahydrofuran; water
参考文献
Eli Lilly and Company
Patent: US6156748 A1, 2000 ;
反应条件
1: thionyl chloride / hexane / Heating
2: 76 percent / hexane
View Scheme
参考文献
Ivakhnenko, E. P.; Shif, A. I.; Prokof'ev, A. I.; Olekhnovich, L. P.; Minkin, V. I.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 2.2 p. 319 - 328
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 2 p. 357 - 367
反应条件
toluene-4-sulfonic acid
1.) to 100 deg C over 40 min; 2.) from 100 to 142 deg C over 3 h;
参考文献
Pastor, Stephen D.; Hessell, Edward T.
Journal of Organometallic Chemistry, 1987 , vol. 328, p. 263 - 274
反应条件
triethylamine; chlorodiphenylphosphine oxide in ethyl acetate
T=20°C;
参考文献
Isobe, Yoshiaki; Tobe, Masanori; Inoue, Yoshifumi; Goto, Yuso; Obara, Fumihiro; Isobe, Masakazu; Hayashi, Hideya
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 3 p. 309 - 312
参考文献
Centre International de Recherces Dermatologiques Galderma (Cird Galderma)
Patent: US5200550 A1, 1993 ;
反应条件
titanium tetrachloride in dichloromethane
参考文献
THE PROCTER and GAMBLE COMPANY
Patent: EP251408 B1, 1991 ;
