4-(4-羟基苯基)哌啶-4-醇合成路线 （共 5 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=18 - 25°C; 20 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BRADBURY, Robert, Hugh; RABOW, Alfred, Arthur
Patent: WO2010/131022 A1, 2010 ;
Location in patent: Page/Page column 58-59 ;
WO 2010/131022 A1
反应条件
hydrogen; 10percent Pd/C in ethanol T=25°C; Hydrogenation; P=2585.81 Torr; 62 h;
参考文献
Guzikowski, Anthony P.; Tamiz, Amir P.; Acosta-Burruel, Manuel; Hong-Bae, Soo; Cai, Sui Xiong; Hawkinson, Jon E.; Keana, John F. W.; Kesten, Suzanne R.; Shipp, Christina T.; Tran, Minhtam; Whittemore, Edward R.; Woodward, Richard M.; Wright, Jon L.; Zhou, Zhang-Lin
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 984 - 994
反应条件
1: tetrahydrofuran 2: 46 percent / H2 / Pd(OH)2 / methanol / 6 h / 20 °C / 3040 Torr View Scheme
参考文献
Guzikowski, Anthony P.; Tamiz, Amir P.; Acosta-Burruel, Manuel; Hong-Bae, Soo; Cai, Sui Xiong; Hawkinson, Jon E.; Keana, John F. W.; Kesten, Suzanne R.; Shipp, Christina T.; Tran, Minhtam; Whittemore, Edward R.; Woodward, Richard M.; Wright, Jon L.; Zhou, Zhang-Lin
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 984 - 994
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 65 percent / tetrahydrofuran; hexane / 2 h / -78 °C 2.1: 67 percent / H2 / 10percent Pd/C / ethanol / 62 h / 25 °C / 2585.81 Torr View Scheme
参考文献
Guzikowski, Anthony P.; Tamiz, Amir P.; Acosta-Burruel, Manuel; Hong-Bae, Soo; Cai, Sui Xiong; Hawkinson, Jon E.; Keana, John F. W.; Kesten, Suzanne R.; Shipp, Christina T.; Tran, Minhtam; Whittemore, Edward R.; Woodward, Richard M.; Wright, Jon L.; Zhou, Zhang-Lin
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 984 - 994
反应条件
1: tetrahydrofuran 2: 46 percent / H2 / Pd(OH)2 / methanol / 6 h / 20 °C / 3040 Torr View Scheme
参考文献
Sato, Susumu; Komoto, Teruo; Kanamaru, Yoshihiko; Kawamoto, Noriyuki; Okada, Tomomi; Kaiho, Terumitsu; Mogi, Kinichi; Morimoto, Shinichi; Umehara, Norimitsu; Koda, Tadayuki; Miyashita, Akira; Sakamoto, Takao; Niino, Yasuhiro; Oka, Tetsuo
Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 2 p. 292 - 297
