6-氯-2,3,4,9-四氢-1H-咔唑-1-酮合成路线 （共 17 条）
反应条件
hydrogenchloride in acetic acid T=120°C; 0.333333 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/110999 A1, 2004 ;
Location in patent: Page 28 ;
反应条件
hydrogenchloride; acetic acid T=120°C; 0.333333 h;
参考文献
Gudmundsson, Kristjan; Samano, Vicente
Patent: US2009/170906 A1, 2009 ;
反应条件
acetic anhydride; bis-[(trifluoroacetoxy)iodo]benzene T=20°C; 0.166667 h;
参考文献
Shi, Hao; Guo, Tianjian; Zhang-Negrerie, Daisy; Du, Yunfei; Zhao, Kang
Tetrahedron, 2014 , vol. 70, # 17 p. 2753 - 2760
反应条件
1: With sodium hydroxide; water T=20°C; 0.25 h; 2: With water; acetic acid Fischer indole synthesis; 5 h; Reflux;
参考文献
Sheng, Rong; Shen, Li; Chen, You-Qin; Hu, Yong-Zhou
Synthetic Communications, 2009 , vol. 39, # 6 p. 1120 - 1127
反应条件
1: 14.8 percent / POCl3 / 0.33 h / 70 - 80 °C 2: 59 mg / active MnO2 / CHCl3 / 0.83 h / Ambient temperature 3: 53 mg / 50percent KOH aq. / ethanol / 0.08 h / Heating View Scheme
参考文献
Murakami; Ishii
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 3 p. 699 - 710
反应条件
1: 59 mg / active MnO2 / CHCl3 / 0.83 h / Ambient temperature 2: 53 mg / 50percent KOH aq. / ethanol / 0.08 h / Heating View Scheme
参考文献
Murakami; Ishii
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 3 p. 699 - 710
反应条件
1: H2O / 20 °C 2: trifluoroacetic acid / 90 °C View Scheme
参考文献
Li, Xingnan; Vince, Robert
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 9 p. 2942 - 2955
反应条件
1: H2O / 20 °C 2: trifluoroacetic acid / 90 °C View Scheme
参考文献
Li, Xingnan; Vince, Robert
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 9 p. 2942 - 2955
反应条件
potassium hydroxide in ethanol 0.0833333 h; Heating;
参考文献
Murakami; Ishii
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 3 p. 699 - 710
反应条件
1: 1.) NaNO2, conc. HCl; 2.) 50percent KOH aq. / 1.) water; 2.) EtOH, r.t., 30 min 2: 1.356 g / acetic acid / 0.75 h / Heating View Scheme
参考文献
Murakami; Ishii
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 3 p. 699 - 710
