in tetrahydrofuran T=20°C;

in benzene 1 h; Ambient temperature;

1: potassium dimethylmalonate With triethylamine; magnesium chloride in acetonitrile T=20°C; 4 h; 2: N-(2'-naphthoyl)imidazole in acetonitrile T=20°C;

1: hydroxylamine / acetonitrile; water / 14 h / 23 °C 2: 4-nitrophenylsulfonyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 °C / |Inert atmosphere View Scheme