(2R,4R)-叔丁基 4-羟基-2-(羟基甲基)吡咯烷-1-羧酸合成路线

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141850-54-6(2R,4R)-叔丁基 4-羟基-2-(羟基甲基)吡咯烷-1-羧酸

参考文献

Jing, Qing; Li, Huiying; Roman, Linda J.; Martasek, Pavel; Poulos, Thomas L.; Silverman, Richard B.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 1 p. 56 - 60

135042-12-5N-Boc-顺式-4-羟基-D-脯氨酸

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141850-54-6(2R,4R)-叔丁基 4-羟基-2-(羟基甲基)吡咯烷-1-羧酸

参考文献

Fransson, Rebecca; McCracken, Alison N.; Chen, Bin; McMonigle, Ryan J.; Edinger, Aimee L.; Hanessian, Stephen
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 10 p. 969 - 973

14044-65-6硼烷四氢呋喃络合物+

135042-12-5N-Boc-顺式-4-羟基-D-脯氨酸

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141850-54-6(2R,4R)-叔丁基 4-羟基-2-(羟基甲基)吡咯烷-1-羧酸

参考文献

Takeda Pharmaceutical Company Limited
Patent: EP1553074 A1, 2005 ;
Location in patent: Page/Page column 55 ;

1070-19-5N-重氮基氨基甲酸叔-丁基酯

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141850-54-6(2R,4R)-叔丁基 4-羟基-2-(羟基甲基)吡咯烷-1-羧酸

参考文献

Nakamura, Takako; Matsuyama, Haruo; Kamigata, Nobumasa; Iyoda, Masahiko
Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3783 - 3789

2584-71-6顺式-4-羟基-D-脯氨酸

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141850-54-6(2R,4R)-叔丁基 4-羟基-2-(羟基甲基)吡咯烷-1-羧酸

参考文献

Nakamura, Takako; Matsuyama, Haruo; Kamigata, Nobumasa; Iyoda, Masahiko
Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3783 - 3789

114676-47-0顺式-4-羟基-D-脯氨酸甲酯

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141850-54-6(2R,4R)-叔丁基 4-羟基-2-(羟基甲基)吡咯烷-1-羧酸

参考文献

Jing, Qing; Li, Huiying; Roman, Linda J.; Martasek, Pavel; Poulos, Thomas L.; Silverman, Richard B.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 1 p. 56 - 60

24424-99-5二碳酸二叔丁酯

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141850-54-6(2R,4R)-叔丁基 4-羟基-2-(羟基甲基)吡咯烷-1-羧酸

参考文献

BRISTOL-MYERS SQUIBB COMPANY; ELLSWORTH, Bruce, A.; JURICA, Elizabeth, A.; SHI, Jun; EWING, William, R.; YE, Xiang-Yang; WU, Ximao; ZHU, Yeheng; SUN, Chongqing
Patent: WO2014/78609 A1, 2014 ;