1: ethyl acetoacetate With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; Inert atmosphere; 2: With n-butyllithium in tetrahydrofuran T=0°C; 0.25 h; Inert atmosphere; 3: (E,E)-3,7,11-trimethyl-2,6,10-dodecatrienyl bromide in tetrahydrofuran T=0°C; 1.5 h; Inert atmosphere;

1: NaCH(CO2Et)COCH3 With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.75 h; Inert atmosphere; 2: (E,E)-3,7,11-trimethyl-2,6,10-dodecatrienyl bromide in tetrahydrofuran; hexane T=0°C; Inert atmosphere; 3: With dipotassium hydrogenphosphate in tetrahydrofuran; hexane

1: enolate sodique de l'acetylacetate d'ethyle With n-butyllithium in tetrahydrofuran; hexane T=0°C; Metallation; 0.333333 h; 2: (E,E)-3,7,11-trimethyl-2,6,10-dodecatrienyl bromide in tetrahydrofuran; cyclohexane Alkylation; 0.5 h;

暂无反应条件数据

1: 58 percent / KH / tetrahydrofuran 2: 82 percent / bis(benzonitrile)palladium(II) chloride; triphenylarsine; Ag2O / K3PO4*nH2O / dioxane / 5 h / 20 °C 3: 72 percent / diisobutylaluminum hydride / toluene / 1 h / -78 °C View Scheme

1: 4-(N,N-dimethlyamino)pyridine; N,N'-dimethyl-N,N'-propyleneurea; triethylamine / 3 h / -30 - 20 °C / Inert atmosphere 2: iron (III) acetylacetonate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0.5 h / -40 - -20 °C / Inert atmosphere 3: diisobutylaluminium hydride / toluene / 1 h / -70 °C / Inert atmosphere View Scheme

sodium hydroxide in tetrahydrofuran T=20 - 60°C;