7-氯-7-甲酰基庚酸乙酯合成路线 （共 12 条）
反应条件
1: AlCl3 2: aq. NaOH View Scheme
参考文献
Fliedner,L.J. et al.
Journal of Medicinal Chemistry, 1976 , vol. 19, p. 202 - 208
反应条件
aluminium trichloride
参考文献
Journal of Medicinal Chemistry, , vol. 19, p. 202 - 208
反应条件
1: chloroform; triethylamine / Erwaermen des Reaktionsgemisches mit wss. Salzsaeure; Erwaermen des danach erhaltenen Reaktionsprodukts mit wss. Kalilauge. 2: potassium acetate; aqueous isopropyl alcohol 3: potassium hydroxide; diethylene glycol; hydrazine hydrate View Scheme
参考文献
Huenig; Luecke
Chemische Berichte, 1959 , vol. 92, p. 652,660
反应条件
1: n-butyl-magnesium chloride With zinc(II) chloride in diethyl ether T=-78 - 0°C; 2: 7-chlorocarbonylheptanoic acid ethyl ester With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; diethyl ether T=0 - 20°C; 2 h;
参考文献
WO2005/23314 A1, ;
Page/Page column 109 ;
WO 2005/023314 A1
反应条件
in diethyl ether 2 h; Ambient temperature;
参考文献
Synthesis, , # 1 p. 50 - 54
反应条件
1: 1.) Et3N, 2.) H2O 2: 85 percent View Scheme
参考文献
Kondo; Miyazaki; Yada; et al.
Agricultural and Biological Chemistry, 1984 , vol. 48, # 5 p. 1263 - 1267
参考文献
Brockman; Fabio
Journal of the American Chemical Society, 1957 , vol. 79, p. 5027
反应条件
aluminium trichloride T=20°C; Friedel-Crafts reaction;
参考文献
Chemical and pharmaceutical bulletin, , vol. 51, # 5 p. 565 - 573
反应条件
sulfuric acid in benzene Yield given;
参考文献
Zhou, Qingzhong; Yang, Yanan; Chen, Zhikuan; Sun, Anna
Chemistry and Physics of Lipids, 1998 , vol. 95, # 1 p. 1 - 9
反应条件
pyridine in dichloromethane
T=0 - 20°C;
参考文献
Menger, Fredric M.; Galloway, Ashley L.; Chlebowski, Mary E.; Wu, Shaoxing
Journal of the American Chemical Society, 2006 , vol. 128, # 43 p. 14034 - 14035
