5-(6-氨基-2-碘-9H-嘌呤-9-基)-N-乙基-3,4-二羟基四氢-2-呋喃甲酰胺合成路线 （共 7 条）
反应条件
trifluoroacetic acid in water T=20°C; 1.08333 h;
参考文献
BRISTOL-MEYERS SQUIBB PHARMA COMPANY
Patent: WO2004/104017 A2, 2004 ;
Location in patent: Page 18; 33 ;
反应条件
1: With thionyl chloride in ethanol T=0 - 20°C; 2: With sodium hydrogencarbonate in ethanol; water pH 8; 3: With ethylamine T=-20 - 20°C;
参考文献
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Patent: EP1194440 B1, 2005 ;
Location in patent: Page/Page column 10 ;
参考文献
Cristalli; Eleuteri; Vittori; Volpini; Lohse; Klotz
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2363 - 2368
反应条件
in tetrahydrofuran T=110°C; 3 h; Microwave irradiation;
参考文献
Foitzik, Richard C.; Devine, Shane M.; Hausler, Nicholas E.; Scammells, Peter J.
Tetrahedron, 2009 , vol. 65, # 43 p. 8851 - 8857
反应条件
1: 74 percent / p-toluenesulfonic acid / 1 h / Ambient temperature 2: 76 percent / KOH, aq. KMnO4 / 20 h / Ambient temperature 3: 85 percent / 50percent aq. HCOOH / 1.5 h / 80 °C 4: 65 percent / SOCl2 / Ambient temperature 5: 85 percent / -20 - 20 °C View Scheme
参考文献
Cristalli; Eleuteri; Vittori; Volpini; Lohse; Klotz
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2363 - 2368
反应条件
1: 76 percent / KOH, aq. KMnO4 / 20 h / Ambient temperature 2: 85 percent / 50percent aq. HCOOH / 1.5 h / 80 °C 3: 65 percent / SOCl2 / Ambient temperature 4: 85 percent / -20 - 20 °C View Scheme
参考文献
Cristalli; Eleuteri; Vittori; Volpini; Lohse; Klotz
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2363 - 2368
反应条件
1: 85 percent / 50percent aq. HCOOH / 1.5 h / 80 °C 2: 65 percent / SOCl2 / Ambient temperature 3: 85 percent / -20 - 20 °C View Scheme
参考文献
Cristalli; Eleuteri; Vittori; Volpini; Lohse; Klotz
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2363 - 2368
