2-碘-9-[(3Xi)-2,3-O-异亚丙基-beta-D-苏-呋喃戊糖基]-9H-嘌呤-6-胺合成路线 （共 10 条）
反应条件
4 h; Ambient temperature;
参考文献
Homma, Hiroshi; Watanabe, Yohko; Abiru, Toichi; Murayama, Toshihiko; Nomura, Yasuharu; Matsuda, Akira
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2881 - 2890
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=-25°C;
参考文献
METHYLGENE INC.
Patent: US2008/132525 A1, 2008 ;
Location in patent: Page/Page column 45 ;
反应条件
sodium hydrogencarbonate; toluene-4-sulfonic acid in acetone
参考文献
US6232297 B1, ;
US 6232297 B1
反应条件
1: 85 percent / I2; CH2I2; isoamyl nitrite / CuI / Heating 2: 83 percent / NH3 / methanol 3: camphorsulfonic acid View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 6 p. 1087 - 1092
反应条件
1.1: HMDS; (NH4)2SO4 / Heating 1.2: 83 percent / TMSOTf / 1,2-dichloro-ethane 2.1: 85 percent / I2; CH2I2; isoamyl nitrite / CuI / Heating 3.1: 83 percent / NH3 / methanol 4.1: camphorsulfonic acid View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 6 p. 1087 - 1092
反应条件
1.1: HMDS; (NH4)2SO4 / Heating 1.2: 83 percent / TMSOTf / 1,2-dichloro-ethane 2.1: 85 percent / I2; CH2I2; isoamyl nitrite / CuI / Heating 3.1: 83 percent / NH3 / methanol 4.1: camphorsulfonic acid View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 6 p. 1087 - 1092
反应条件
1: 83 percent / NH3 / methanol 2: camphorsulfonic acid View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 6 p. 1087 - 1092
反应条件
1: NaIO4, Ru2O / acetonitrile; CHCl3; H2O / Ambient temperature 2: 78 percent / thionyl chloride / methanol / 2 h / Ambient temperature 3: 99 percent / bis(triphenylphosphine)palladium dichloride, CuI, Et3N / dimethylformamide / 2 h / 70 °C 4: 80 percent / NH3 / methanol / 3 h / 80 °C 5: 96 percent / 80percent aq. TFA / 2 h / Ambient temperature View Scheme
参考文献
Homma, Hiroshi; Watanabe, Yohko; Abiru, Toichi; Murayama, Toshihiko; Nomura, Yasuharu; Matsuda, Akira
Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2881 - 2890
反应条件
2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; [bis(acetoxy)iodo]benzene in water; acetonitrile T=0 - 20°C; Jones Oxidation; 22.5 h;
参考文献
BRISTOL-MEYERS SQUIBB PHARMA COMPANY
Patent: WO2004/104017 A2, 2004 ;
Location in patent: Page 18; 32 ;
反应条件
1: 76 percent / KOH, aq. KMnO4 / 20 h / Ambient temperature 2: 85 percent / 50percent aq. HCOOH / 1.5 h / 80 °C 3: 65 percent / SOCl2 / Ambient temperature 4: 85 percent / -20 - 20 °C View Scheme
参考文献
Cristalli; Eleuteri; Vittori; Volpini; Lohse; Klotz
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2363 - 2368
