10-氯-10-氧代癸酸甲酯合成路线 （共 37 条）
反应条件
thionyl chloride T=50°C; 3 h;
参考文献
Kalgutkar, Amit S.; Crews, Brenda C.; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1692 - 1703
反应条件
1: 85 percent / KOH / methanol; acetonitrile; diethyl ether / 54 h / 0 °C 2: (COCl)2 / toluene / 4 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 16 p. 4253 - 4256
反应条件
1: H2SO4 / Heating 2: Ba(OH)2 / methanol / 20 h / 20 °C 3: SOCl2 / benzene / Heating View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 36, # 7 p. 982 - 995
反应条件
1: zinc-copper; ethyl acetate; toluene 2: methanol; concentrated aqueous KOH-solution 3: acetic acid; amalgamated zinc; concentrated aqueous hydrochloric acid View Scheme
参考文献
Breusch et al.
Fette und Seifen, 1959 , vol. 61, p. 891
反应条件
1: diethyl ether / Anschliessendes Erwaermen mit Kupfer(II)-oxid in Benzol. 2: platinum; methanol; benzene / Hydrogenation 3: dioxane; sodium sulfate; zinc chloride / Erwaermen des Reaktionsprodukts mit Raney-Nickel und Methanol View Scheme
参考文献
Hnevsova et al.
Collection of Czechoslovak Chemical Communications, 1956 , vol. 21, p. 1459,1465
反应条件
1: benzene / Behandeln des Reaktionsprodukts mit wss.-aethanol. Kalilauge 3: Raney nickel; methanol / Hydrogenation.unter Druck View Scheme
参考文献
Bergstroem et al.
Acta Chemica Scandinavica (1947-1973), 1952 , vol. 6, p. 1157,1160, 1169
反应条件
1: aq. NH3 / 0 °C 2: Br2; CH3ONa / Heating 3: aq. HCl / Heating View Scheme
参考文献
Kalgutkar, Amit S.; Crews, Brenda C.; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1692 - 1703
反应条件
Yield given. Multistep reaction;
参考文献
Balzer, Th.; Budzikiewicz, H.
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 10 p. 1367 - 1368
反应条件
1: 71 percent / AlCl3 / CH2Cl2 / 24 h / Heating 2: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C 3: 96 percent / Et3N; DMAP / CH2Cl2 / 7 h / 20 °C 4: 49 percent / LiBr / dimethylformamide / 24 h / 120 °C 5: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C 6: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C 7: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C View Scheme
参考文献
Jung; Joe; Seong; Park
Synthetic Communications, 2001 , vol. 31, # 18 p. 2735 - 2741
