N,N-二甲基-4-甲基苯甲酰胺合成路线 （共 38 条）
反应条件
1: alpha-chloropyridine With magnesium in tetrahydrofuran
T=40°C; 2 h;
2: 4-MeC6H4CONMe2 in tetrahydrofuran
T=40°C; 5 h;
3: With water; ammonium chloride in tetrahydrofuran
T=10°C;
参考文献
VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION
Patent: WO2007/141803 A2, 2007 ;
Location in patent: Page/Page column 6 ;
反应条件
in tetrahydrofuran
T=20 - 25°C; 1 h; Inert atmosphere;
参考文献
Rao, G. Venkateswara; Swamy, B. Narayana; Kumar, P. Hareesh; Reddy, G. Chandrasekara
Synthetic Communications, 2009 , vol. 39, # 10 p. 1835 - 1846
反应条件
1: 4-MeC6H4CONMe2 With bis(trichloromethyl) carbonate in tetrachloromethane
T=0°C;
2: 1-methyl-pyrrole in tetrachloromethane
T=40 - 50°C; Vilsmeier-Haack reaction; 1 h;
3: With sodium hydroxide in tetrachloromethane
参考文献
Shi; Su; Shan
Journal of the Indian Chemical Society, 2005 , vol. 82, # 11 p. 1019 - 1021
反应条件
PPA; sodium acetate; trichlorophosphate
Multistep reaction;
参考文献
Carson, John R.; Davis, Nancy M.
Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 839 - 843
反应条件
hydroxide in water
T=100°C; Rate constantMechanism;
参考文献
Slebocka-Tilk, H.; Brown, R. S.
Journal of Organic Chemistry, 1988 , vol. 53, # 6 p. 1153 - 1156
参考文献
Perregaard,J. et al.
Bulletin des Societes Chimiques Belges, 1977 , vol. 86, p. 321 - 328
反应条件
1: 4-MeC6H4CONMe2 With bis(trichloromethyl) carbonate in tetrachloromethane
T=0°C;
2: pyrrole in tetrachloromethane
T=40 - 50°C; Vilsmeier-Haack reaction; 1 h;
3: With sodium hydroxide in tetrachloromethane
参考文献
Shi; Su; Shan
Journal of the Indian Chemical Society, 2005 , vol. 82, # 11 p. 1019 - 1021
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane
T=-78°C; 1.5 h; Inert atmosphere;
2: With ammonia; iodine in tetrahydrofuran; hexane; water
T=0 - 20°C; Inert atmosphere;
参考文献
Suzuki, Yusuke; Yoshino, Takumi; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 21 p. 3809 - 3814
