(R)-9-(2-羟基丙基)腺嘌呤合成路线 （共 12 条）
反应条件
1: LiOt-Bu / dimethylformamide; tetrahydrofuran / 1 h / 30 - 35 °C 2: 1.) bromotrimethylsilane, 2.) NaOH / 1.) acetonitrile, reflux, 2.) H2O, pH 3 View Scheme
参考文献
Holy, Antonin; Masojidkova, Milena
Collection of Czechoslovak Chemical Communications, 1995 , vol. 60, # 7 p. 1196 - 1212
反应条件
1.1: Mg(O-t-Bu)2 / 1-methyl-pyrrolidin-2-one / 70 - 74 °C 2.1: chloro-trimethyl-silane; sodium bromide / 1-methyl-pyrrolidin-2-one / 0 - 75 °C 3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 45 °C 3.2: 5.5 h / 45 - 50 °C 4.1: isopropyl alcohol / 2 h / 50 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 14, # 5 p. 1194 - 1201
