（1R.2R)-环己烷-1,2-二羧酸二甲酯合成路线 （共 12 条）
反应条件
sulfuric acid T=40°C; 18 h;
参考文献
RANBAXY LABORATORIES LIMITED; JAYACHANDRA, Suresh, Babu; GAHLOT, Udaibhan, Singh; SINGH, Tarun, Kumar; KHANDURI, Chandra, Has
Patent: WO2012/131606 A1, 2012 ;
Location in patent: Page/Page column 13 ;
反应条件
sulfuric acid T=10 - 50°C; 20 h;
参考文献
RANBAXY LABORATORIES LIMITED; JAYACHANDRA, Suresh Babu; GAHLOT, Udaibhan Singh; SINGH, Tarun Kumar
Patent: WO2014/37886 A1, 2014 ;
Location in patent: Page/Page column 19; 20 ;
反应条件
in diethyl ether T=0°C; Inert atmosphere;
参考文献
Malihi, Farzad; Clive, Derrick L. J.; Chang, Che-Chien; Minaruzzaman
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 996 - 1013
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 24 h; Yield given;
参考文献
Ito, Yoshio N.; Ariza, Xavier; Beck, Albert K.; Bohac, Andrej; Ganter, Camille; et al.
Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2071 - 2110
反应条件
1: 96 percent / (NH4)2SO4, phosphate buffer / 96 h / Ambient temperature; pig-liver esterase, pH 7.0 2: 1.) K(t-BuO); 2.) concd. H2SO4 / 1.) THF, r.t., 1 h; 2.) reflux, 8 h 3: H2 / 10percent Pd/C / ethyl acetate / 24 h View Scheme
参考文献
Ito, Yoshio N.; Ariza, Xavier; Beck, Albert K.; Bohac, Andrej; Ganter, Camille; et al.
Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2071 - 2110
反应条件
1: 1.) K(t-BuO); 2.) concd. H2SO4 / 1.) THF, r.t., 1 h; 2.) reflux, 8 h 2: H2 / 10percent Pd/C / ethyl acetate / 24 h View Scheme
参考文献
Ito, Yoshio N.; Ariza, Xavier; Beck, Albert K.; Bohac, Andrej; Ganter, Camille; et al.
Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2071 - 2110
反应条件
1: ethanol / 6.5 h / -70 - 20 °C / Resolution of racemate 2: hydrogenchloride / water 3: sulfuric acid / 18 h / 40 °C View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; JAYACHANDRA, Suresh, Babu; GAHLOT, Udaibhan, Singh; SINGH, Tarun, Kumar; KHANDURI, Chandra, Has
Patent: WO2012/131606 A1, 2012 ;
反应条件
1: acetic acid; sodium nitrite / dimethyl sulfoxide / 8 h / 40 °C / |Inert atmosphere 2: diethyl ether / 0 °C / |Inert atmosphere View Scheme
参考文献
Malihi, Farzad; Clive, Derrick L. J.; Chang, Che-Chien; Minaruzzaman
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 996 - 1013
反应条件
1: With diisobutylaluminium hydride in toluene T=-5 - 20°C; 6 h; Inert atmosphere; 2: With hydrogenchloride; water in toluene T=-5 - 40°C; 13 h;
参考文献
RANBAXY LABORATORIES LIMITED; JAYACHANDRA, Suresh, Babu; GAHLOT, Udaibhan, Singh; SINGH, Tarun, Kumar; KHANDURI, Chandra, Has
Patent: WO2012/131606 A1, 2012 ;
Location in patent: Page/Page column 13 ;
反应条件
1.1: diisobutylaluminium hydride / toluene / 6 h / -5 - 20 °C / Inert atmosphere 1.2: 13 h / -5 - 40 °C 2.1: triethylamine / chloroform / 5 h / 0 - 20 °C View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; JAYACHANDRA, Suresh, Babu; GAHLOT, Udaibhan, Singh; SINGH, Tarun, Kumar; KHANDURI, Chandra, Has
Patent: WO2012/131606 A1, 2012 ;
